Xanax (generic name alprazolam) is a benzodiazepine medication used to treat panic disorders, anxiety, and depression. Common side effects of Xanax include drowsiness, lack of coordination, memory loss, and early-morning anxiety.
Xanax breaks down in the liver via an enzyme called CYP3A4, which is inhibited by CBD. Taking CBD could potentially increase the amount of time Xanax is in the system and prolong or increase the likelihood of unwanted side effects. CBD may one day be considered an alternative to Xanax as various research, including a 2011 study published in the journal Neuropsychopharmacology, has documented the cannabinoid’s potential anti-anxiety properties.
Eliquis (generically called apixaban) is a blood thinner used to lower the risk of stroke or a blood clot in veins, the heart, the lungs, and the legs following knee or hip replacement surgery. Eliquis increases the risk of severe bleeding, and patients taking Eliquis are typically prescribed precise dosages by their doctor.
Should I take CBD with statins?
According to a 2011 study published in the journal Life Sciences, it is possible that CBD has an inhibitory effect on CYP2C19, the enzyme that metabolizes Plavix. This could cause Plavix to remain longer in the body and weaken its overall effects. Further research is required to determine whether this could lower Plavix’s effectiveness in preventing heart attacks.
More research is required to confirm potential interactions between CBD and acetaminophen. Patients looking to take both simultaneously should consult their physician.
Patients taking Eliquis should speak to their doctor before using CBD products.
A previously cited 2017 study titled, “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study” published in the journal JCI Insight, supports CBD’s ability to lower blood pressure. Researchers also suggest that the anxiety- and stress-reducing properties of CBD may contribute to the overall ability to lower blood pressure. However, CBD taken with blood pressure medication or beta-blockers could potentially cause both drugs to double up on each other and lower blood pressure to unhealthy levels.
Your medication dosage and frequency are calculated based on how these enzymes would work in a typical body, without the influence of things like CBD. So you might be taking the prescribed amount at the recommended time, but take it with CBD and you could be amplifying the effects, or reducing them.
The CBD industry is still fairly young, so while we have a reasonably good idea about how it works in the body and how CBD gummies might interact with other drugs, there’s also a lot that’s yet to be discovered. In this article, we’ll talk about what we’ve learned so far and what it means for you if you take medications.
On the other hand, if your body isn’t breaking down the drug quickly enough, you might still have high levels in your system by the time you take your next dose. That could intensify any side effects and potentially put you at risk of harm.
CBD and drug interactions
This is where you could run into problems.
Any foreign substance that you ingest has to be metabolised, or broken down. For a huge number of prescription medications, that happens mostly in your liver, thanks to a large family of enzymes called cytochrome P450, or CYP450.
In some cases, CBD induces, or speeds up, the activity of a CYP450 enzyme. This can cause it to break down drugs faster than it usually would. In other cases, CBD can inhibit a CYP450 enzyme, which means that the enzyme breaks down substances more slowly than it usually would.
If your body is breaking down your medication too quickly, it’s going to leave your system sooner than it should. This might mean that you’re not getting the full effects of the medication, for as long as you need them.
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One such prodrug for example is codeine which is metabolized into morphine. Similarly, lisdexamfetamine under the brand names Vyvanse and Concerta are two other popular ADHD medications which also fall into this category.
CBD is most widely known and has been popularized as being used for seizure disorders such as epilepsy, but has also proven to be effective in helping to relieve the symptoms of other conditions. These include anxiety, depression, schizophrenia, inflammatory and neuropathic pain, Parkinson’s disease, Crohn’s and other forms of inflammatory bowel disease, as well as certain types of cancer.
Let’s find out why.
As mentioned, and contrary to popular belief and anecdotal evidence, CBD is not a biologically inert compound. Rather, CBD has a complex pharmacokinetic and pharmacodynamic profile similar to any other medication, and has the potential to interact with other medications and medical conditions.
For instance, any therapeutic compound that is metabolized by the CYP system has the potential of being affected by CBD. One indication that your medicine might be metabolized by the CYP system is if your pharmacist told you not to eat grapefruit, or watercress or use St. John’s Wort or goldenseal supplements. However, this is by no means a solid test and you should always check with your pharmacist of doctor first (more on that later).
The above mentioned list of drugs that could interact with CBD is by no means exhaustive and does not include all the medications on which CBD may have an interaction with. Similarly, not all the medication categories listed above will necessarily cause and interaction (although if you are taking one of these medications it is recommended to rather err on the side of caution).