Tramadol And CBD Oil Interaction In Dogs

Dog CBD drug interaction can be confusing. Keep yourself informed and check out which meds are possible to use with CBD Oil CBD oil is good for your dogs and is super safe for them. However, it might have a negative effect when mixed with some meds. Read to know more. Accurate Education: Cannabidiol (CBD) – Side Effects and Drug Interactions Cannabidiol (CBD) has promise for many medical applications although they are not yet well defined nor are the

Dog CBD: Drug Interaction You Need To Avoid

In our previous post, we discussed CBD Oil Drug Interactions: What Should We Know? More and more people are interested in using CBD as a complementary treatment for many health problems. The same goes for pets. We want them to be healthy and happy and that’s why CBD is a great option. Dog CBD drug interactions are very similar to human medication. In this article, we talk about this in more detail.

Natural Foods: Inhibitors and Inducers

Very similar to humans, our pets metabolize medication in the liver and mostly with the help of special enzymes P450. These enzymes are very important as they can easily break down all the extra chemicals that drugs through in the blood and safely remove it from the body.

An interesting fact that some foods in combination with medication can inhibit or induce our enzymes.

According to this Wikipedia list, such foods as broccoli, cauliflower, brussel sprouts or even chargrilled meat act as inducers when interacting with certain medication. And foods like grapefruit, turmeric, cumin, echinacea, herbal teas and coffee act as inhibitors of enzymes and increase drug effects on the body.

CBD products like oil and other supplements act in the same way as it also natural and plant-based. Moreover, in proper combination, CBD can act as an inhibitor and an inducer as well!

With our human bodies everything is clear, if we have discomfort, we can ask advice or go to a doctor. But our pets can’t talk, and they trust us with whatever we feed them. Let’s see how CBD can act in certain drug combinations and how that helps to understand our pets better.

Dog CBD Oil Drug Interaction Tips

We know CBD is very safe to use on its own and the only side effect you can experience if you take to much is an upset stomach. But let’s see what happens when your pet has a specific health condition.


Many clinical trials proved that CBD reduces seizure frequency in dogs and cats. And even more effective if given with traditional anti-seizure meds like clobazam or phenobarbital. Basically, you can adjust the dosage. Reduce the dosage of traditional medication with many nasty side effects and increase CBD dosage. That works effectively with minimum side effects for your dog.


Painkillers commonly prescribed for injured, aging and chronically ill pets. Carprofen, gabapentin, meloxicam and etodolac are the most popular NSAIDs used for pets. We know that side effects are not great and can lead to liver failure, upset GI and compromised immune system.

Even though CBD is a great pain reliever on it’s own, it also can increase the effect of painkillers. Which gives an opportunity to significantly reduce regular NSAID dosage and use natural oil as a main treatment in the routine. As a result, fewer side effects and more actual pain relief.


CBD oil drug interaction is very important when it comes to cancer. CBD is a well-known product to use in oncology and has great anti-tumor properties. It helps relieve really bad side effects of chemotherapy such as anemia, pain and nausea.

In addition, many kinds of research shows that CBD enhances the effects of chemo and fights cancer more efficiently! Of course, you want to consult your doctor on how you can adjust CBD dosage so it will benefit the cancer treatment of your dog.


Usually such medication as Xanax, Amitriptyline, Ativan, Paxil, Zoloft and many others, vets are prescribing for dogs with anxiety, phobias and depression. On the other side, such meds like Xanax can be addictive and provoke bad side effects like dizziness, drowsiness, diarrhea, vomiting and even blurred vision.

CBD oil drug interactions might increase some of the side effects. That’s why dosage is key. You can use CBD oil for pets to improve bad side effects and decrease current medication dosage. Naturally, CBD will increase the effectiveness of minimum dosage but with less side effects!

CBD is A Safe And Natural Way to Help Your Pet!

We get a lot of questions about using CBD to replace prescription or OTC medications. Most medications can be entirely replaced with CBD, or dramatically reduced while being used in cohesion with CBD. Pawt4Paws CBD is a pure isolate CBD oil that exclusively contains hemp CBD. We test our oil with a 3rd party to ensure that there is virtually no THC and no harmful pesticides. Your pet’s safety is our number priority.

Pawt4Paws was started for a dog with seizures, and we always go back to wanting the best we can possibly give to you and your fur family!

Consult With Your Vet

To know for sure how strong dog CBD oil drug interaction is, it is best to consult with your vet. It’s good to keep in mind that some drug interactions are not always a bad thing. There is a great chance that your CBD oil can be an unexpectedly amazing solution in dog treatment. Our pets safety and well being is always our top priority, please consult with your vet and make your vet is aware that you are using CBD!

Can Cbd Oil For Dogs Be Used With Other Medications

World consumption of CBD products for pets is growing. The factor that has fueled CBD’s appeal, in addition to its advantages in treating a wide range of medical conditions, is its low potential for adverse side effects. Today, a growing number of people are interested in adopting CBD as an additional treatment for a variety of health issues affecting both themselves and their four-legged pets. CBD is a fantastic choice if you’re searching for a solution to keep them healthy and content. CBD drug interactions in dogs are quite similar to those in people. We go into more information about this in this article.

Article Description:

Cannabidiol (CBD) has the potential to interact with other veterinary drugs, which is something owners need to be aware of. This article starts by highlighting the use of CBD Oil for dogs and examines the potential of CBD oil in enhancing the effect of prescription medications. The article further deals with the crucial question- Can CBD oil for dogs be used with other medications? We continue to explain, in detail, the medications not compatible with CBD oil. The article finally concludes with the significance of seeing your veterinarian before providing your dog any kind of CBD product if they are receiving other medications.

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CBD Oil for Dogs

Cannabidiol, also known as CBD, is a naturally occurring compound that can be found in the cannabis plant. Your pet buddies can benefit greatly from medicinal cannabis and the wide variety of advantages it offers. According to studies, strain, stress, anxiety, and other bone and heart issues can positively affect your dogs as well. It also interacts with the animal’s body receptors like how it does with humans. Dog treats, oils, lotions, topicals, and tinctures made from CBD and hemp is a good source for your four-legged pals to receive all the benefits they are entitled to. If you’re seeking a natural way to boost their health, relax their mind, and reduce their joint pain, using CBD oil seems to be the best approach. It contributes to the happiness and contentment of your dog. Dogs experiencing situational or relocation anxiety, behavior issues, or insomnia can also benefit from the use of CBD.

Does CBD enhance the effect of other drugs?

Some medications may work better when certain substances, like CBD, are added. Some medical professionals, researchers, and veterinarians are investigating how this can be advantageous since less of the drug needs to be provided to be effective because it stays in the bloodstream longer.

For instance, some studies have suggested that CBD may improve the effects of some medications due to its impact on CYP450 pathways and other intricate signaling processes in the central nervous system. This might enable medical professionals to lower the dosage of those medications without lowering their efficacy.

This boosting effect, which is frequently referred to as a “catalytic activity,” is still very much under study. Ongoing research demonstrates this impact on:

  • NSAIDs and narcotics for treating pain
  • Anti-seizure drugs for seizures in patients
  • Radiotherapy drugs used in a pancreatic cancer investigation.

Can CBD Oil for dogs be used with other medications?

The reaction between CBD and the other medication your dog is taking is known as a dog CBD interaction. Due to reports of positive behavioral and health impacts, more and more people are now adding CBD to their dog’s ordinary routine. Even though CBD has anti-inflammatory, immune-modulating, and anxiety-relieving properties, it is important to be careful with potential drug interactions with the prescription medication of your dogs.

The use of medical marijuana or CBD oil by your dog, while they are taking prescribed medication may cause an interaction. This then has an impact on the cytochrome P450 family of liver enzymes.

Without getting too scientific, it is known that this specific group of enzymes is in charge of metabolizing or breaking down around 60% of clinically prescribed drugs available today, including tramadol, Xanax, and antidepressants.

Let’s break things down as simply as possible. Enzyme P450 operates by introducing oxygen to the drug, making it liquid and making it simpler for the kidneys to process.

Hemp oil may prevent some enzymes from working, which would alter the liver’s ability to perform metabolic tasks.

In other words, if both prescribed medication and CBD oil are consumed at the same time, there are high chances that the enzymes will only actually be able to break down one of the two. As a result, pharmaceutical drugs will often stay in the body for a longer period and have a greater impact. However, the right CBD dosage has a significant impact on this interaction. It’s unlikely that your dog would notice much of a difference if you give him a tiny dose of hemp oil alongside the prescribed medication.

In light of this, you may be wondering which medications may interact.

Drug Interactions: Medications not compatible with dog CBD products.

As we’ve already established, not all drugs cause this drug interaction; just some do. More than half of the pharmaceutically prescribed drugs available can be metabolized by enzymes, while the fate of the other half is unknown.

To be safe, here is a list of recognized medications that, when administered in excessive doses, may interact with hemp products:

  • Benadryl
  • Antibiotics
  • Depressants
  • Morphine
  • General anesthesia

If your pet is on one or more of the medications listed above, it is crucial to consult with your vet before you purchase CBD products.

Let’s take a closer look at what happens when your pet is on prescribed medication and whether CBD may be used in conjunction with that.

CBD oil interferes with anti-seizure medication:

Sudden unusual brain activity that results in a temporary loss of body control is what causes seizures. That usually results in a dog losing consciousness, collapsing over on its side, having muscle cramps, tremors, frequently shrieking, and losing control of its intestines and bladder. Numerous clinical studies have shown that CBD decreases the incidence of seizures in dogs and cats. Furthermore, it is considerably more effective when combined with common anti-seizure medications like carbamazepine or phenobarbital. The dosage can be changed. Increase CBD dosage while decreasing dosage of conventional drugs with undesirable side effects. That gives your dog the best results with the fewest adverse effects.

CBD Oil interferes with Arthritis Medication:

It’s quite improbable that CBD would, in the vast majority of situations, interfere with the metabolism of medications used to treat osteoarthritis and other aggressive joint disorders. Veterinarians frequently prescribe painkillers for old, persistently unwell, and wounded dogs. The most widely used NSAIDs for pets include gabapentin, metformin, and nonsteroidal anti-inflammatory drugs (NSAIDs), which are safe for dogs to treat pain and joint problems. However, research suggests that CBD won’t interact with any NSAID medications other than Voltaren. While NSAIDs are frequently administered to dogs, simple over-the-counter drugs like Tramadol should only be administered to your dog under the guidance of your veterinarian because they can easily cross the safety boundary in canines.

CBD Oil and its interaction with cancer therapy:

Drug interactions involving CBD oil are crucial when it comes to cancer. CBD is a very well-known substance with excellent anti-tumor characteristics that are used in cancer. It aids in the relief of chemotherapy’s extremely unpleasant side effects, including bleeding, discomfort, and anxiety.

Further, a wide range of studies demonstrates that CBD increases the effects of chemotherapy and kills cancer more effectively! Of course, you should speak with your veterinarian about how to change the CBD dosage for your dog’s cancer therapy.

CBD Oil and its interaction with blood pressure medication:

Although high blood pressure and hypertension are more common in humans, our dogs are also prone to the condition and require similar treatment. CBD may seem like a smart idea to use in conjunction with medications made to achieve the desired results as it can lower blood pressure. It possibly aids people with hypertension. However, caution is urged. Although CBD can be used in conjunction with blood pressure drugs, it is advised that you first talk to your veterinarian about it. Aldosterone converting enzyme (ACE) inhibitors, h2-receptor antagonists (ARBs), corticosteroids, and carbamazepine are a few of the drugs used to manage high blood pressure. As a result, if your veterinarian likes the benefits CBD is providing for your pet but notices that it interacts with the medication, he might alter the medication.

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CBD oil and its interaction with antidepressant medication:

Veterinarians frequently prescribe drugs like Alprazolam, Tricyclic antidepressants, Xanax, Prozac, Risperdal, and many others for dogs who experience stress, anxiety, and sorrow. On the other hand, drugs like Xanax can be habit-forming and have unpleasant side effects like sleepiness, headache, nausea, dysentery, and even clouded eyesight.

Drug interactions with CBD oil could make some negative effects worse. Therefore, the correct dosage is crucial. To reduce negative side effects and dosage of current medications, utilize CBD oil for pets. Naturally, CBD will make a lower dose more effective while having fewer negative effects!

Discuss CBD oil drug interactions with your veterinarian.

Numerous health advantages of CBD can help improve your dog’s condition in both subtle and profound ways. Research has demonstrated that CBD oil and other CBD products are remarkably low-risk choices for the advantages they bring. While it is possible to combine CBD with other medications, doing so may increase the likelihood that the medication will have negative consequences. Although not all pharmaceuticals can interact, most medications have the potential to do so.

Your best bet for advice is your pet’s veterinarian if your dog is taking medicine and you have questions regarding CBD and its potential for drug interactions. Even though CBD may interact with the drugs your pet is on, your veterinarian can safely determine if CBD is still the best option for them. The best of both worlds can frequently be achieved by timing out the pills or altering the dose of the other drugs or CBD.

Even when there is a chance for drug interaction, according to current research, CBD can offer a treatment plan as an indispensable tool for enhancing health without having any real adverse reactions.


The use of CBD has many health benefits, including pain relief. Even though there may be drug interactions that result in side effects with certain medications, the advantages outweigh the disadvantages. However, as is often said, too much of anything is good for nothing; veterinarians frequently caution that too much CBD may mess with your pet’s body chemistry.

Therefore, it should always be your primary responsibility to speak with your veterinarian before using any kind of pet medication for your dog’s well-being.

Accurate Education: Cannabidiol (CBD) – Side Effects and Drug Interactions

Cannabidiol (CBD) has promise for many medical applications although they are not yet well defined nor are the mechanisms by which it works well understood. When taking CBD one must be aware of potential side effects and drug interactions CBD may have with other medications.

Links to other Pertinent Educational Pages:
Cannabidiol (CBD):
  • CBD – Introduction
  • CBD – Clinical Use Overview
  • CBD – Dosing, Products and Formulations
  • CBD – Treatment of Addiction
  • CBD- Treatment of Anxiety
  • CBD – Treatment of Dental Disease
  • CBD – Synergy between CBD and PEA
  • CBD – Side Effects and Drug Interactions
  • CBD – Mechanisms of Action

The medical information on this site is provided as a resource for information only, and is not to be used or relied upon for any diagnostic or treatment purposes and is not intended to create any patient-physician relationship. Readers are advised to seek professional guidance regarding the diagnosis and treatment of their medical concerns.

Key to Links:
  • Grey text – handout
  • Red text – another page on this website
  • Blue text – Journal publication
This Page:
  • CBD: Side Effects
  • CBD: Safety
  • CBD: Drug Interactions
  • CBD: Metabolism of CBD
  • CBD: Resources and References
CBD: Side Effects

CBD has been determined to be safe, with no fatal overdoses on record. It is generally well tolerated with minimal or mild side effects only. CBD does not affect motor function or memory and does not appear to have the potential for physical dependence (e.g. withdrawal and tolerance), nor is it associated with abuse or addiction.

The side effects of CBD are mild and include:

  • Low blood pressure
  • Dry mouth
  • Light-headedness
  • Drowsiness.
CBD: Safety

CBD offers great therapeutic potential but remains poorly studied. Human CBD short-term studies illustrate low toxicity and only mild adverse effects. However, it is unknown what side effects may be caused by prolonged use. It is important to note that there are few to no long term studies on CBD administration in healthy people even though short term trials show CBD to be safe and well tolerated. Studies also do not assess prolonged use in chronically ill people who often take medications continuously for many years. Even animal studies only evaluate chronic CBD treatment for up to several months, which may mimic prolonged use in people, but differences cannot be excluded.

There is no evidence for CBD to have abuse or dependence potential, and there is no evidence of public health related problems associated with the use of pure CBD.

CBD: Drug Interactions

Cannabinoids and Opioids

There appears to be a synergistic analgesic (pain-relieving) benefit when cannabinoids are added to opioid treatment for pain in which there is a greater-than-additive benefical effect with the addition of cannabinoids. Studies indicate a trend towards reduced use of opioids when patients taking opioids add cannabinoids to their regimen. It is not uncommon for patients started on cannabinoids to be able to taper down or off opioids.

Interestingly, animal studies suggest that cannabinoids may reduce the development of tolerance to the analgesic benefits of opioids, resulting in less need for opioid dose escalation.

There is no enhancement of cardiorespiratory suppression from opioids with the addition of cannabinoids due to the very low density of cannabinoid (CB) receptors in brainstem cardiorespiratory centers. There does not appear to be any significant interactions with opioids regarding a cannabinoid effect on the metabolism of most opioids.

However, there is research showing that CBD may inhibit CYP2D6, one of the liver enzymes responsible for metabolizing tramadol and codeine. Because the analgesic benefits from tramadol and codeine come from their active metabolites resulting from CYP2D6 metabolism, these two opioids may be less effective if taken with CBD.

P-glycoprotein (P-gp) Transporters

Another way in which medications may interact with one another is through their effect on drug transport systems, especially the P-glycoprotein (P-gp) system. The P-gp transporters transport medications and metabolites out of the central nervous system and brain through the blood-brain barrier into the blood. The activity of P-gp transporters can significantly impact the effect of drugs such as morphine, oxycodone and methadone on the brain by reducing their levels in the brain. Early findings indicate that CBD significantly inhibits P-gp-mediated drug transport, suggesting CBD could potentially increase brain levels of morphine and other opioids that are P-gp substrates thus enhancing their impact. CBD may also influence the absorption and disposition of other coadministered compounds that are P-gp substrates.

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UDP-glucuronosyltransferase (UGT) family of enzymes

The UDP-glucuronosyltransferase (UGT) family of enzymes found in the liver and kidneys play an important role in the metabolism of medications. These enzymes attach glucoronide to medications to facilitate their elimination. The interaction between UGTs and cannabinoids have not yet been thoroughly examined but a recent 2021 study evaluated the potential of Δ9-THC, CBD, and cannabinol (CBN), and their major metabolites, to inhibit the activity of UGT enzymes.

The highest inhibition was seen by CBD against the glucuronidation activity of UGTs 1A9, 2B4, 1A6, and 2B7 but strong inhibition of UGT1A9 and UGT2B7 was also found with THC and CBN. Regarding the metabolites of these cannabinoids, there was weak or no inhibition was found.

This inhibition of UGT activity by CBD, THC and CBN may play an important role in drug-drug interactions. Major cannabinoids found in the plasma of cannabis users inhibit several UDP-glucuronosyltransferase (UGT) enzymes, including UGT1A6, UGT1A9, UGT2B4, and UGT2B7. This study identified the potential of cannabinoids to inhibit all the major kidney UGTs as well as the two most abundant UGTs present in liver. This study suggests that as all three major kidney UGTs are inhibited by cannabinoids, greater drug- drug interaction effects might be observed from co-use of cannabinods and therapeutics that are cleared renally.

Smoking – Tobacco and Marijuana

Smoking marijuana and tobacco both induce CYP1A2 through activation of the aromatic hydrocarbon receptors, and this effect between the two products is additive. Of note: this effect is based on the smoke associated with the smoking of marijuana or tobacco, not the drugs in the smoke. As a result of this CYP1A2 enzyme being induced, in other words more CYP1A2 enzyme is manufactured, medications that are metabolized by CYP1A2 will be broken down faster, blood levels will be decreased and the therapeutic effects of the drug will be reduced. CYP1A2 is the enzyme responsible for metabolizing such drugs as caffeine, tizanidine (Zanaflex), duloxetine (Cymbalta), methadone, olanzapine (Zyprexa) and melatonin.

When one suddenly stops smoking either tobacco, marijuana or both, the induction effect is quickly reversed and the levels of CYP 1A2 enzyme rapidly return to previous levels (downregulation) over a few days. When this occurs in an individual chronically taking one of the medications metabolized by CYP 1A2, the blood levels of this medication may quickly rise leading to the potential for increased side effects and toxicity from the medication.

This is especially significant in medications that have a narrow therapeutic index such as tizanidine (Zanaflex), in which even small increases in blood levels may be associated with increased side effects. It is therefore important to reduce doses of these medications in the first few days after suddenly stopping smoking either tobacco, marijuana or both to avoid possible toxicity from the medication. Due to body size and gender-related variables, this reduction is especially warranted in small females.

While the CYP 1A2 enzyme is not a major enzyme in the metabolism of methadone, it has been reported that methadone levels can dangerously increase with smoking cessation. As a rule of thumb, it has been recommended that a stepwise daily methadone dose reduction of approximately 10% be engaged until the fourth day after smoking cessation.

Alcohol and Benzodiazepines

The combination of cannabinoids with alcohol and benzodiazepines may increase sedation and cognitive impairment.

NSAIDS (Non-Steroid Anti-inflammatory Drugs)

It has been reported that NSAIDs such as ibuprofen and naproxen, particularly indomethacin, can partially antagonize the effects of THC, although the mechanism responsible is not fully understood.

Anticholinergic drugs (tricyclic antidepressants (TCAs) and some muscle relaxers)

Medications with anticholinergic activity such as amitriptyline (Elavil) and doxepin, and muscle relaxers such as cyclobenzaprine (Flexeril) may increase the psychoactive side effccts of cannabinoids.

CBD and Piperine

Blood levels and duration of action of CBD may be increased if CBD is accompanied by ingestion of piperine, an alkaloid found in black pepper (Piper nigrum) . Piperine has been found to reduce metabolic breakdown of CBD in the intestines and the liver. Furthermore, piperine may suppress the elimination of CBD (and THC) from the brain by inhibiting the P-gp transporter mechanism involved, leading to prolonged effects of CBD and THC.

Metabolism of CBD

The way in which many drug interactions occur is through their impact on how a drug is metabolized. Understanding how CBD is metabolized provides insight as to how other drugs may interact with CBD.

CBD is extensively metabolised in the liver, primarily to 7-OH-CBD which is then metabolised further into as many as 100 metabolites that are excreted in feces and urine. Seven CYP enzymes have been identified as metabolising CBD: CYP1A1, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5, but the two main ones are CYP3A4 and CYP2C19.

Although research is lacking, the metabolites formed from CBD are believed to be present in the body at pharmacologically significant concentrations. Pharmacological studies of CBD metabolites are scarce but suggest biological activities not directly related to CB receptors. The pharmacological effects observed with CBD may be attributed at least in part to its metabolites.

CBD: Drug-Metabolic Interactions

The major cannabanoids, THC and CBD are both metabolized in the liver by the CYP450 enzymes 2C9, 2C19 and 3A4. Drugs that inhibit these enzymes may enhance or prolong the effects of THC and CBD. Whether people with genetic variants of these enzymes may experience altered effects from cannabinoids is not known. In one study, potential drug–drug interactions of THC/CBD oro-mucosal spray (Sativex, nabiximols) in combination with CYP450 inducers and inhibitors were assessed using various dose regimens. The antibiotic rifampicin, an inducer of CYP3A4, significantly reduced the peak plasma concentration of CBD, while the antifungal ketoconazole, a CYP3A4 inhibitor, nearly doubled the peak plasma concentration of CBD. However, the moderate CYP2C19 inhibitor omeprazole (Prilosec), a proton-pump inhibitor used to treat gastroesophageal reflux disease (GERD), did not significantly alter the pharmacokinetics of CBD.

CBD has been identified as a potent inhibitor of CYP2D6 which may have significant impact on the metabolism of medications that are broken down by CYP2D6, including hydrocodone (Norco, Vicodin, Zohydro, Hysingla). As such, use of CBD especially at high doses with tramadol, codeine or hydrocodone may significantly reduce the analgesic effectiveness of these opioids.

Limited evidence also suggests that CBD may significantly inhibit CYP2C19, the enzyme responsible for metabolizing many medications including:

  1. Anticoagulants such as clopidogrel (Plavix),
  2. Tricyclic antidepressants such as amitriptyline (Elavil)
  3. SSRI antidepressants including citalopram Celexa) and e scitalopram (Lexapro)
  4. Proton pump inhibitors such as omeprazole (Prilosec) and pantoprazole (Protonix)
  5. Other drugs including indomethacin (Indocin), diazepam (Valium) and propranolol (Inderal).

As a result this may lead to elevated blood levels of these medications and their associated side effects.