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sativa cbd oil topical effects

Taking CBD by mouth. You absorb CBD that you swallow in capsules, gummies, food, or liquid, through the digestive tract. This makes absorption slow and dosing a bit challenging due to several factors, including recent meals, unknown effects of stomach acids, the delayed onset of effect which is one to two hours, and other factors.

Either way, depending on the type of issue you’re trying to treat and pain management you’re seeking, it is possible to get the effects of CBD topically or orally—if what you’re taking is made for that kind of use. But you wouldn’t eat hand cream, right? So would you put CBD oil on your skin?

Lately we’ve been hearing a lot about the “best CBD oil for…” any number of issues. Sometimes, that’s exactly what they’re looking for—the best CBD oil for sleep or certain skin conditions.

Can You Use Oral CBD Oil Topically?

A CBD topical is any CBD-infused lotion, cream, or salve that can be applied directly to the skin. They don’t have enough tetrahydrocannabinol or THC, of course, to get you high.

Some of the most common types of CBD topicals that you might find on the market include these, and here are some of their applications:

A lot of this is related to the endocannabinoid system (ECS), a biological system all mammals share. The ECS is mostly composed of enzymes, endocannabinoids, and CB1 and CB2 receptors for the endocannabinoids. The ECS regulates many functions in humans, including memory, appetite, pain sensation, mood, reproduction, and sleep.

However, many have other cannabinoids and terpenes and are therefore capable of producing the entourage effect–the effect that happens when all of the plant’s cannabinoids and terpenes work together to produce benefits.

CBD oil may reduce the risk of heart disease by alleviating hypertension (high blood pressure) in certain people, suggests a 2017 study in JCI Insight.  

Here are a few tips to help you find the best CBD oil:

Heart Health

For this study, nine healthy men took either 600 mg of CBD or the same dose of a placebo. According to the researcher, those treated with CBD had lower blood pressure before and after exposure to stressful stimuli (including exercise or extreme cold).

However, the effect of CBD on each addiction type was often very different. With opioid addiction, for example, CBD showed little effect in minimizing withdrawal symptoms in the absence of THC. By contrast, CBD on its own appeared effective in minimizing drug-seeking behaviors in users of cocaine, methamphetamine, and other psychostimulant drugs.

There is some evidence that CBD interacts with seizure medications such as Onfi (clobazam) and boosts their concentration in the blood. Further research is needed.

Wang GS, Bourne DWA, Klawitter J, et al. Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020. View abstract.

Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 2011;10(7):1161-72. View abstract.

Watzl, B., Scuderi, P., and Watson, R. R. Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro. Int J Immunopharmacol. 1991;13(8):1091-1097. View abstract.

Interactions ?

Pretzsch CM, Voinescu B, Mendez MA, et al. The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD). J Psychopharmacol. 2019:269881119858306. View abstract.

Novotna A, Mares J, Ratcliffe S, et al. A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex), as add-on therapy, in subjects with refractory spasticity cause by multiple sclerosis. Eur J Neurol 2011;18(9):1122-31. View abstract.

Hurd YL, Spriggs S, Alishayev J, et al. Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial. Am J Psychiatry. 2019:appiajp201918101191. View abstract.

Matsuyama SS, Fu TK. In vivo cytogenetic effects of cannabinoids. J Clin Psychopharmacol 1981;1(3):135-40. View abstract.