In June 2018, the U.S. Food and Drug Administration (FDA) approved Epidiolex, a CBD oral solution used for the treatment of certain rare forms of epilepsy in children under 2—Dravet syndrome and Lennox-Gastaut syndrome. Both are exceptionally rare genetic disorders causing lifelong catastrophic seizures that begin during the first year of life.
CBD oil may reduce the risk of heart disease by alleviating hypertension (high blood pressure) in certain people, suggests a 2017 study in JCI Insight.
Scientists believe that CBD reduces nerve pain by binding to glycine receptors in the brain that regulate the speed at which nerve signals pass between nerve cells.
Since some CBD oils contain trace amounts of THC, you should avoid driving or using heavy machinery when taking CBD oil, particularly when first starting treatment or using a new brand.
According to a 2012 study in the Journal of Experimental Medicine, rats injected with inflammatory chemicals in their hind feet experienced less inflammation and neuropathic pain when treated with an oral dose and spinal injection of CBD.
Many of these interactions are mild and require no adjustment to treatment. Others may require a drug substitution or the separation of doses by several hours.
Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.
(Courtesy of Populum)
When it comes to conditions like insomnia, CBD’s clinical research scorecard is more mixed. Some studies have suggested that the substance can actually increase wakefulness. Others, though, have found that a CBD tincture or oil taken a couple of hours before bedtime can help induce a sense of balance that can help sleep come more easily. A 2016 report, for instance, found that a CBD-rich oil, administered orally, helped to alleviate the symptoms of both anxiety and insomnia in one patient suffering from post-traumatic stress disorder.
When taken to relief the symptoms of epilepsy, CBD is typically administered orally. Researchers have found that this same method of dosing may be effective in using CBD to treat social anxiety disorder, generalized anxiety disorder, and related conditions. Evidence also suggests that this cannabinoid could be helpful in treating the symptoms of obsessive compulsive disorder.
What is a tincture?
Since the doses are relatively small, tinctures can be administered in a variety of ways. For patients looking to take their CBD with food, a dose of tincture can be mixed into a meal like soup or pasta. It can also be added easily to drinks like coffee and tea; an evening cup of chamomile paired with CBD tincture stands to be even more relaxing than usual.
CBD can be administered in many forms, from smoking a cannabis strain that produces a lot of the molecule to consuming it in edibles. Among the most popular methods—especially for individuals trying a cannabis-based treatment for the first time—is through a tincture.
Tinctures can also be taken sublingually, or by applying them underneath the tongue. This method of delivering CBD tincture is already common in epilepsy treatments. Some research has found that this delivery method makes cannabinoids more easily and consistently available to the body than other oral alternatives.
As cannabis–based therapeutic products become more widely available and accepted, it’s natural to have questions. After all, a lot of the treatments on the market today weren’t around just a couple of years ago. While cannabinoids like CBD show a lot of promise in treating a host of conditions, it can be hard to know how to introduce them into an existing healthcare routine. Today, we explore the role CBD tinctures can play in your well-being.
Granjeiro EM, Gomes FV, Guimaraes FS, et al. Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress. Pharmacol Biochem Behav 2011;99(4):743-8. View abstract.
The following doses have been studied in scientific research:
Crippa, J. A., Zuardi, A. W., Martin-Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., and Fusar-Poli, P. Cannabis and anxiety: a critical review of the evidence. Hum.Psychopharmacol. 2009;24(7):515-523. View abstract.
Insufficient Evidence for
Liver disease: People with liver disease may need to use lower doses of cannabidiol compared to healthy patients.
Bornheim LM, Everhart ET, Li J, Correia MA. Characterization of cannabidiol-mediated cytochrome P450 inactivation. Biochem Pharmacol 1993;45(6):1323-31. View abstract.
Izzo AA, Borelli F, Capasso R, et al. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 2009;30(10):515-27. View abstract.
Yamaori S, Maeda C, Yamamoto I, Watanabe K. Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids. Forensic Toxicol 2011;29:117-24.