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Koi CBD Review: Trusted CBD for All Needs (Sponsored)
The CBD industry continues to grow with what seems like new brands and products showing up daily. With tons of CBD options on the market, knowing which brands to trust and which products work can feel overwhelming.
Koi, a reputable CBD brand based in California, is an excellent place to start if you’re new to CBD. They offer a wide range of CBD products, from oils to balms and edibles, and are known for their tasty flavors, quality, and effectiveness.
Our Verdict: Koi CBD
Overall, Koi CBD is a trustworthy brand with quality products that promote relaxation and balance. In addition, the brand is transparent about its creation process and makes its lab results available for every CBD product on its website.
Customers love them, with nearly five-star ratings on most of their products. So whether you’re looking for CBD hemp flower, CBD-infused bath products, gummies, or pet-friendly CBD options, Koi is likely to have something to suit your needs.
About Koi CBD
Founded in 2015, Koi has as its mission to offer natural ways to help customers feel and live their best. Their promise to consumers is to provide consistent, high-quality CBD by constantly finding better ways to run their business. This pursuit includes finding the best practices so they can give users better prices, education, and experiences.
Koi puts quality, safety, and consistency at the forefront and are ambassadors of responsible farming, extraction, and distribution. They infuse all their products with USA-grown hemp that they extract through a strict vendor validation process. Each CBD batch comes with full traceability from plant to finished product.
Koi CBD Product Highlights
Koi CBD offers a range of products for different uses and health benefits. Some of the crowd favorites include:
Koi Naturals Hemp Extract CBD Oil Tincture
Koi Naturals Hemp Extract CBD Oil Tincture in Orange blends Koi PRIZM broad-spectrum hemp extract with natural orange flavor oil for a therapeutic experience to bring balance to your life.
- Benefits: This Koi CBD tincture brings a calming sensation, and many users find it easier to sleep and de-stress after a dose.
- Product options: This tincture in orange flavor comes in four strengths. You can purchase a bottle of 250 mg for $29.99, 500 mg for $44.99, 1000 mg for $69.99, or 2000 mg for $124.99. It also comes in additional flavors: strawberry, lemon, spearmint, peppermint, and natural hemp.
- How to use it: Shake the bottle and use the dropper to measure the recommended dose. Place the dropper under the tongue and release the oil. It is suggested that you eat before taking this tincture. Wait at least three hours before taking a second dose, and do not take more than three doses in a day. This tincture is an oral oil, and you should not use it with a vape.
Koi CBD Gummies – Nighttime Rest
Discover the sleep you deserve with the Koi Nighttime Rest CBD Gummies. These vegan-friendly gummies bring the perfect sense of calm right before bedtime so you can enjoy a quality night’s sleep.
Benefits: These Koi CBD gummies have 5 mg of melatonin per serving mixed with the Koi Prizm broad-spectrum CBD to promote quality sleep. Each piece contains 10 mg of CBD, making dosing quick and convenient for every-night usage.
Koi Complete Full Spectrum CBD Gummies
Try the Koi Complete Full Spectrum CBD Gummies if you’re looking for a delicious way to bring CBD into your routine. The CBD gummies include Delta-9 THC and minor cannabinoids for a more substantial effect.
- Benefits: The small dose of Delta-9 THC in the gummies gives your CBD relaxation a slightly more potent effect. They’re great when you need extra edge taken off after a long day.
- Product options: You can purchase these Koi CBD gummies in a 20-count container for $39.99. Flavor options include grape, pineapple, and pomegranate. Each container contains 500 mg of CBD and 100 mg of THC.
- How to use it: Take one gummy up to three times a day. Each gummy is one dose and contains 25 mg of CBD and 5 mg of Delta-9 THC.
Koi Naturals CBD Balm
Koi Naturals Hemp Extract CBD Balm brings an enjoyable blend of hemp extract and natural oils that melts on contact, leaving your skin restored and smooth. This Koi Naturals CBD balm is infused with Koi PRIZM broad-spectrum CBD and dozens of natural oils, including organic coconut oil, eucalyptus leaf oil, and aloe vera leaf juice.
- Benefits: Koi CBD Balm is a therapeutic healing balm perfect for sore muscles or joints. You can also apply it to dry or irritated skin for an immediate soothing sensation.
- Product options: The Koi Naturals CBD balm comes in three options. You can purchase a travel-size container with 150 mg of CBD for $19.99, a full-size container with 500 mg of CBD for $39.99, or 1,000 mg for $69.99.
- How to use it: Dry the affected area and massage a liberal amount of Koi CBD balm into the skin, wherever you need it most. Repeat throughout the day as needed. Store it in a cool, dry place away from light, heat, and humidity to preserve the quality of the balm.
Koi CBD Customer Reviews
Koi CBD has nearly 15,000 5-star reviews from verified customers.
With nearly 1,500 reviews and an overall rating of 4.8, the Koi Nighttime Rest CBD Gummies are one of the company’s most popular products. Customers claim a better, quality night’s rest after a dose of these CBD edibles.
Verified buyer Mary S. says, “I was a bit skeptical about these helping my sleep, but I finally got a good night’s sleep after using these. I was finally able to stay asleep and actually felt sleepy before bed.”
Colleen Q, verified buyer, agrees with Mary S., saying, “Koi CBD gummies are the best out there. I consider KOI a trusted brand, and the quality of the product is fantastic. I HIGHLY recommend KOI for your CBD needs!”
The Koi Complete Full Spectrum CBD Gummies are also a hit among customers, with an average 4.8 rating from 234 reviews. One verified buyer, Kathryn R., says, “This product is the Goldilocks of CBD-based gummies. It gives you exactly what you need—not too much and not too little—just right. They have a nice flavor, and I like that they are not made with too much sugar or corn syrup.”
Customers also rave about the Koi Naturals Hemp Extract CBD Balm, with a 4.8 rating from 330 reviews. Verified buyer Sandra S. says, “I am really happy with Koi CBD balm. It helps relieve the ache of strained muscles, and an added bonus, it is a great smelling lotion for the skin when you rub it in.”
Another verified buyer of the Koi CBD balm says, “This CBD balm is very effective at helping the skin on my hands to heal. My cuticles take a beating with cold weather, exposure to water, hand sanitizer, and sanitizing wipes. They crack and sometimes bleed. Not only is it unsightly, but it’s also painful. This balm, overnight, promotes the healing of my cuticles and my fingernails and hands. Amazing!”
Similarly, the Koi Naturals Hemp Extract CBD Oil Tincture in Orange Flavor earned an average 4.8 rating from 494 reviews. Verified buyer David B. says, “I have tried other CBD products with not much effect. The KOI CBD extract delivered what I was hoping for and is a great price compared to other brands.”
Tonya C., another verified buyer, says she uses the oil to help her sleep. She shares, “I sleep much better, and I can definitely tell when I forgot to use it.”
What You Should Know Before Buying Koi CBD Products
Understanding a brand’s reputation, price comparison, policies, and company values is vital in choosing a CBD brand.
Although Koi CBD has had some controversy in the past, most customers can agree that the brand is generally trustworthy and transparent about its ingredients, manufacturing process, and products overall.
Awards and Recognition
In 2021, the Koi CBD Natural Broad Spectrum Tincture won the Best CBD Tincture award at the USA CBD Expo Excellence Awards, the country’s largest CBD and Hemp show.
They also won Best in Show CBD Packaging at the CBD Expo Tour West. Additionally, many publications and customers list them as a favorite CBD and Delta-8 brand.
Pricing and Discounts
Koi CBD products are slightly more expensive than other CBD companies. On the lower end, Koi’s CBD Oil Tinctures (30 mL) start at $29.99 and go all the way up to $124.99 at the highest strength. For the most potent options, Koi Complete Full Spectrum CBD Tinctures range from $79.99-$199.99 depending on strength.
6-count gummies are an affordable option at $9.99, with 20-count gummies ranging from $24.99 to $34.99. The more costly options have a higher percentage of THC.
Koi offers 25% off to all military members, medical professionals, law enforcement personnel, and financially disadvantaged persons. To receive the discount, visit the Koi Cares website, click on the group you belong to, create an account, and you’ll get a one-time discount code. You can request one code every 24 hours.
Koi CBD Rewards
Koi also has a CBD rewards program that customers can join. As a member, you’ll receive offers and discounts when you make purchases directly from Koi. You can participate by creating an account. Then you earn points with each purchase by following Koi on Instagram and Facebook and by writing a product review.
You use those points for exclusive discounts on future purchases.
Extraction and Production Methods
All Koi CBD products use USA-grown and extracted hemp. Their hemp is selected and tested to ensure agricultural quality and consistency.
The extraction process for the Koi PRIZM broad-spectrum hemp preserves the naturally occurring CBD, terpenes, and phytocannabinoids, so the THC levels are below 0.001%. Koi also carefully produces and packages each batch to minimize cross-contamination.
The company prides itself on quality products and ensures every batch of Koi CBD is tested multiple times during production using third-party ISO-accredited testing labs.
To ensure THC levels are below the legal requirement, they receive detailed terpenoid and phytocannabinoid profiles for every CBD product. They also test all products for pesticides, solvents, heavy metals, and 100 other contaminants.
You can search the lab results of any Koi product by searching for the unique batch number on their website.
Returns and Refunds Policy
If you receive a damaged product, you may return it to Koi CBD within 30 days by submitting a claim to [email protected] You should include a detailed description of the product damages and pictures in the claim.
Koi will only accept the return if the product is unused and in its original packaging. They also will only accept returns from customers who bought directly from Koi, not a third-party seller.
If you are not satisfied with a product, you can request a full refund within 30 days of the purchase date. You must return the item, and it cannot be more than 50% used. Once Koi receives the item, they will inspect it and notify you of the status of your refund.
The money will get credited to your original payment method if the refund is approved. Refunds are only valid on products purchased directly from Koi CBD.
Standard shipping orders have a 4- to 6-day delivery time. However, if you choose USPS priority shipping, you can expect your order within 2-4 days.
Koi CBD does not ship orders on holidays or weekends. The company is also the first in the CBD industry to offer hand delivery in as little as two hours in major cities.
How to Choose Koi CBD Products
There are a few things to consider when choosing a Koi CBD product. First, you need to identify what benefits you’re hoping to get from the product. Koi breaks down their wide array of products on their website into 6 categories based on health benefits:
- Pain relief
They also have a category for pet products, their collection of pet-friendly CBD treats and oils.
Once you decide on the experience you’re seeking, click into the category from the Koi homepage under “Shop.” You will get directed to a page with a list of products designed to give you the desired benefits.
Some category pages will only have one or two products, making the selection simple. Others, like “relaxation,” have various product types. Browse the options and decide how you want to take the CBD.
If you’re a CBD veteran, consider Koi CBD vape juice.
If you’re new to CBD, you may want to consider gummies. Each gummy has a specific amount of CBD, making it easier to dose. You can start with one gummy and monitor yourself for the effects. If you don’t feel the desired results after 3 hours, take another gummy, but do not exceed more than 3 in one day.
Another good option for individuals new to CBD is tinctures or oils. Tinctures come with a dropper for easy dosing. They also tend to come in many different flavors, so you’ll likely find something that appeals to your taste buds!
Before taking any CBD product, be sure you understand the CBD concentrations of each product. If you’re worried about taking CBD oil or gummies, some of the CBD topicals Koi has available may help with your ailments.
FAQ About Koi CBD
What Koi CBD products are available?
Koi produces various CBD products, including tinctures, vape bars, gummies, lotions, roll-on gels, balms, vape juices, and CBD pet products.
Is Koi CBD FDA-approved?
Do Koi CBD products have THC?
Koi CBD products contain less than 0.001% THC as tested by a third-party ISO-accredited lab. As a result, THC levels are virtually non-detectable, and it’s unlikely you’ll experience extreme effects of THC.
Will Koi CBD show on a drug test?
CBD products won’t usually show up on a drug test. However, there are low levels of THC in Koi CBD products, and some drug tests are sensitive and may misclassify CBD as THC.
If you are subject to regular drug testing, Koi CBD products may not be a good match for you.
What is Koi Natural CBD used for?
Koi Natural CBD products blend naturally flavored oils and other natural ingredients with Koi’s premium PRIZM broad-spectrum hemp extract for an additional sense of relaxation and calming.
Is Koi CBD oil safe for dogs?
Koi CBD makes oils for humans, and you should not use them on your pets. However, Koi does sell pet-friendly CBD products. They carry a wide selection of dog and cat treats and a hemp-extract CBD pet spray.
It’s always best to speak with your vet before starting your pet on CBD products, especially if your animal is on medications or a special diet.
What is Koi CBD oil used for?
Most people use Koi CBD oils to help them relax or sleep. Many users’ reviews say Koi CBD oils help bring a sense of calm and balance to their daily routines.
Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.
Koi CBD Review, Koi Naturals, Natural, 250 mg
We purchased this CBD product and tested it at independent testing facilities to measure levels of CBD, THC, and other cannabinoids and compare the results to the manufacturer’s claims. Here are the results. (Learn more about our review process.)
Total mg Unspecified
Our Lab Tests
From Lab A
From Lab B
* Products tested prior to 2020 were sent to only one independent testing facility.
The unadulterated test results on this page come directly from these certificates of analysis from two independent labs, which we pay directly. These are two independent lab tests of one product, at one point in time. We do not guarantee that all products or labs will produce the same results. Lab results may differ based on the different methodologies of testing used by each lab or inconsistencies in the product. Added ingredients may affect lab results. Volume of creams and edibles may change due to factors such as temperature, and this may impact lab results. Learn more about our review process.
Koi CBD Review
Our Rating: A. Innovate products and flavors with verified levels of CBD.
Koi CBD oil is a high-quality oil with guaranteed therapeutic concentrations of CBD. Their lab analyses check out in our research. Even though they include products like vape and gummies, their products actually contain therapeutic levels of CBD, a rarity in the industry. With cookie-cutter CBD companies, all franchises of one old hemp manufacturer, only the 25% oil and the concentrates actually have therapeutic levels of CBD. Not so with Koi. You can get enough CBD from grape vape or strawberry gummies with Koi. You don’t have to choose between fun or getting the CBD you need for stress and anxiety associated with various medical conditions. These products also contain the ‘entourage’ cannabinoids and terpenes like CBDV, CBG, limonene, and myrcene. We will focus on Koi Full Spectrum CBD oil but also go over information about the other products.
CBD oil can be used under the tongue or added to foods. It may be dissolved in hemp oil or coconut oil. This adds healthy fatty acids and MCTs to the mix. Koi produces CBD tinctures, vapes, topicals, supplements, gummies, and even pet products. Koi provides CBD in various flavors. None of these products will make you high. They are meant as dietary supplements.
Koi sources its hemp from the San Luis Valley between Colorado and New Mexico. This is an arid, sunny region between the valley and the headwaters of the river called the Rio Grande. In this environment, hemp grows resilient, lush, and packed with cannabinoids and terpenes.
Koi hemp oil
|Is its CBD oil?||Yes. It is both CBD oil and hemp oil.|
|Old, the trusted company?||No. Operating since 2015.|
|Contains verified therapeutic levels of CBD?||Yes.|
|Sourced in the United States?||Yes.|
|Sourced in Europe?||No.|
|Certified Organic in the US?||Unknown.|
|Certified Organic by the European Commission?||Unknown.|
|Did the lab test in the United States?||Yes.|
|3 rd Party Testing?||Yes.|
|Do they tell what percentage CBD in a product?||Yes.|
|CO2 extracted?||No. Solvent-free extraction.|
|Functional Website?||Yes. High function.|
From our grading questions above and our research, Koi CBD products get an A. If you have any suspicions about their products, send a sample of the product to a 3 rd party lab and leave a comment telling us your results.
Advantages of Koi Hemp Oil
The advantage of Koi Hemp products is that they provide guaranteed therapeutic levels of CBD in innovative and delicious products. With most companies, you can either have therapeutic levels of CBD, or you can have cool products with cheap hemp oil in them and little CBD.
Koi Vape products actually deliver a therapeutic level of CBD via vape. Most vape products will not deliver you a therapeutic dose even if you vape all day long. Koi has done the math and has the lab analyses to prove it. Even their Tropical Gummies has 10 mg of CBD per gummy! That is unheard of for CBD gummy candies, most of which just have hemp seed oil in them. The hemp seed oil has less than 25 parts per million of CBD.
One potential disadvantage of Koi is that they use a solvent-free extraction process for their CBD. We simply don’t know what this method is or if it produces a product of the caliber of supercritical CO2 extraction, or if it is worse or better. CO2 is the same stuff you breathe out, we know it’s fairly safe to use. Whatever method they use, we don’t know if it is more or less safe than CO2 extraction.
Koi CBD uses the Confident Cannabis lab result reporting system to report lab results for each batch of the product tested by the CannaSafe Labs. Get it? Confident Cannabis handles the lab reporting, CannaSafe laboratories do the testing. We will assume this is a third-party lab. And the lab results are very good, even for the vape products.
Koi prices and products
|CBD Oil||CBD Vape Juice||Devices and Cartridges||CBD for Pets||CBD Gummies||CBD Lotion||KOI CBD Hats|
|Koi Naturals Full-Spectrum CBD, Orange $39.99 – $99.99||CBD Vape Juice,
Pumpkin Spice Latte
$39.99 – $99.99
|Koi Stik by Boulder©
|Koi Naturals Soft Chews
|Koi CBD Tropical Gummies
$9.99 – $29.99
|Koi CBD Orange Hat
|Koi Naturals Full-Spectrum CBD, Lemon Lime
$39.99 – $99.99
|CBD Vape Juice, Blue Koi
$29.99 – $99.99
|Max Battery 380mAH
|Full Spectrum CBD Oil Spray
|Koi Naturals Full-Spectrum CBD, Spearmint
$39.99 – $99.99
|CBD Vape Juice, red koi
$29.99 – $99.99
|Koi Ponds (2 empty pods)
|CBD Combo Pack for Dogs
|Koi CBD Blue Hat
|Koi Naturals Full-Spectrum CBD, Natural
$39.99 – $99.99
|CBD Vape Juice, gold koi
$29.99 – $99.99
|Fitt Pods (2 pre-filled pods)
|Koi Naturals Infused with Koi PRIZM© Proprietary Full Spectrum Blend
$39.99 – $99.99
|CBD Vape Juice, white koi
$29.99 – $99.99
|Koi Naturals Vape Cartridge
|CBD Vape Juice, jade koi
$29.99 – $99.99
|CBD Vape Juice, pink koi
$29.99 – $99.99
Koi Naturals Full-Spectrum CBD Oil
8.5 mg to 34 mg of CBD per dropper.
5 mg to 2 mg of CBD per drop.
INGREDIENTS: coconut oil, Koi PRIZM™ full-spectrum CBD oil, natural orange flavor extract.
Directions: Consume a complete dropper (1mL or 30 drops), from one to three times daily. Hold under the tongue for 15–20 seconds, then swallow. Wait three hours after initial (first time) use to see how the strength level of CBD may affect you.
Koi CBD Vape Juice
Ingredients: 100% natural cannabidiol (CBD) isolate, food-grade vegetable glycerin, propylene glycol, natural & artificial flavorings
Made with 100% natural CBD, with full traceability from the start of extraction
A 3mL vape tank will hold 102 mg of CBD. This is one of the few vape products which clearly shows that you can get therapeutic levels of CBD through vaping. However, it has not been proven that vaping is an effective way to take the CBD.
Ingredients: organic aloe leaf juice, organic coconut oil, glycerin, emulsifying wax NF, stearic acid, organic jojoba seed oil, witch hazel water, organic alcohol extract, vitamin e oil, organic neem seed oil, rosemary leaf extract, Phenoxyethanol, rose distillate, lavender essential oil, organic white willow bark, xanthan gum, Tetrasodium EDTA, naturally occurring CBD in hemp oil.
What are the Main Ingredients for Koi Products?
The main ingredient is Koi CBD isolate or Koi PRIZM full-spectrum CBD blend which is created using a solvent-free method of extraction.
Products may also contain Koi CBD, terpenes, Koi Hemp oil, and/or CBD concentrates. CBD is cannabidiol, the main cannabinoid which produces most of the therapeutic effects by affecting cannabinoid receptors throughout the central nervous system. Terpenes provide fragrance, flavor, and boosts the effects of CBD. CBD Hemp oil drops are the combination of hemp seed oil with CBD isolate from CBD-Rich Whole Hemp Plant Extract.
How to Use
Koi has vape products that have therapeutic CBD levels. These are the first vape products we have seen to provide certificates of analysis showing that there are therapeutic CBD levels.
Koi specializes in flavorful edibles like gummies and flavored hemp oils which can be added to food or used under the tongue.
Koi’s CBD hemp oil drops can be used sublingually.
Koi Lavender is a lotion with therapeutic levels of CBD which can be applied as needed.
Koi CBD oil drops are an oil tincture that can be eaten with food or applied under the tongue.
Koi Naturals Full-Spectrum CBD Oil
One drop contains about 2 mg of CBD
For chronic pain, you might take 20 mg per day or 10 drops.
For non-medical anxiety in people who have epilepsy, up to 300 mg or 150 drops in divided doses throughout the day.
For the inability to sleep well at night, 20 drops, or 40 mg before bedtime daily.
For stress and tension in a person who has Huntington’s disease, 10 mg per kilogram of body weight, or 5 drops per kilogram of body weight.
For stress and tension in a person who has schizophrenia, up to 1,280 mg or 640 drops per day.
For glaucoma, absolutely no more than 40 mg or 20 drops per day. Higher doses can worsen symptoms.
Koi CBD Vape Juice
250mg CBD – 30mLBottleOne standard dropper holds about 10 mg of CBD from Koi Vape Juice. Therefore, a typical beginning dose for anxiety may be about 40 mg or four droppers in divided doses. For chronic pain, you might take 20 mg per day or 2 droppers. For non-medical anxiety in people who have epilepsy, up to 300 mg or 30 droppers in divided doses throughout the day. For the inability to sleep well at night, 4 droppers, or 40 mg before bedtime daily. For stress and tension in a person who has Huntington’s disease, 10 mg per kilogram of body weight, or one dropper per kilogram of body weight.For stress and tension in a person who has schizophrenia, up to 1,280 mg or 128 droppers per day.
For glaucoma, absolutely no more than 40 mg or 4 droppers per day. Higher doses can worsen symptoms.
Use a dime-sized amount to start, then gradually increase the dose until you get the desired effects. Use as much or as little as required.
Manufacturer, Support, Certificates
Norwalk, CA 90650
25% discount on all products to active duty and U.S. military veterans.
Pros and cons
- Has products like vape and gummies which have therapeutic levels of CBD
- Uses a unique lab reporting system so up-to-date labs are always available
- From seed to shelf, the process is transparent
- 3 rd party labs available
- Organic, non-GMO
- No pesticides
- No solvents
- Can be added to food
- Can be taken topically
- Can be used sublingually
- Contains CBD, small amounts of THC, and other cannabinoids
- Contains hemp oil with healthy fatty acids
- Balances the endocannabinoid system
- Contains MCT oil, a healthy fat
- Contains terpenoids
- Our research does not find a CBD concentrate product
- The solvent-free extraction method is unknown
Koi CBD Oil reviews
Review Rating: A. “It’s been wonderful.”
This reviewer in a Facebook group for Ehlers-Danlos syndrome said that Koi CBD oil has worked for her headaches, pain, and inflammation.
Review Rating: C. “Less effective…”
This Facebook reviewer switched to Koi CBD and found it less effective than his previous brand in helping to calm a 5-year-old with socially activated symptoms of ADHD.
Review Rating: A
This Facebook reviewer finds Koi CBD effective for anxiety.
Review Rating: A. “…the only one that worked…”
This Facebook reviewer found Koi vape juice to be the only vape that has worked; however, he feels that it is somewhat pricey.
Review Rating: A. “made me feel relaxed…”
This Reddit user finds Koi vape to be effective for fighting anxiety.
Q&A about Koi CBD
What amount can I vape?
Try using half of your favorite vape juice and half Koi CBD. However, you can also use Koi CBD vape as is.
Can I overdose on CBD?
There is no known overdose for CBD. As always, check the other ingredients in any product for which you may accidentally use more than recommended.
How long does it last? How to store it?
Avoid extremes of heat and cold. CBD can become crystal again from heat or cold. Your vape juice can last one year under proper conditions. Don’t leave it in a hot car or put it in the refrigerator.
Will it affect my work?
Koi CBD products contain no CBD and will not affect your working ability. It will reduce pain and anxiety which may improve working ability.
Will CBD interact with my meds?
You should consult your doctor to eliminate drug interactions. There have not been many reports of adverse drug interactions with CBD.
Is the big number on the bottle the mg amount per serving?
No. That is the amount of CBD in the entire bottle. To find the mg amount, you need to look on the website, under the product name, for ‘CBD concentration’. Products are formulated to provide a therapeutic dose.
Is sublingual better or vape?
Sublingual for now. It is not truly known if vape delivers therapeutic levels of CBD.
Is CBD the same as marijuana?
CBD stands for cannabidiol. It is a non-psychoactive cannabinoid, one among as many as 125 identified cannabinoids in industrial hemp.
CBD is not pot, marijuana, hash, weed, or cannabis sativa. Koi’s CBD products contain no psychoactive THC, only small amounts of therapeutic THC, with large amounts of therapeutic CBD. Marijuana usually contains THC which is psychoactive, CBD does not.
What other cannabinoids are found in hemp oil?
Hemp oil may contain over 125 cannabinoids, including:
- THC (tetrahydrocannabinol)
- THCV (tetrahydrocannabivarin)
- THCA (tetrahydrocannabinolic acid)
- CBV (cannabivarin)
- CBT (cannabicitran)
- CBN (cannabinol)
- CBDA (cannabidiolic acid)
- CBDV (cannabidivarin)
- CBE (cannabielsoin)
- CBG (cannabigerol)
- CBGM (cannabigerol monomethyl ether)
- CBGV (cannabigerovarin)
- CBL (cannabicyclol)
- CBD (cannabidiol)
- CBCV (cannabichromevarin)
- CBC (cannabichromene)
Is it legal?
Yes, with some caveats. CBD and CBDa are legal in most states of the United States as long as it comes along with no more than 0.3% THC. CBD all by itself is pretty much legal everywhere. However, you could still run into legal problems if you have a cop or court which is hell-bent on charging people with violation of marijuana laws or even laws about where you can buy non-psychoactive hemp. This is rare but has happened on occasion.
CBD is legal in many countries, including:
- Costa Rica,
- The Czech Republic,
- South Africa,
- Puerto Rico,
- Northern Ireland,
- Netherlands Antilles,
- Hong Kong,
- S. Virgin Islands,
How does CBD work?
CBD binds to receptors in the central nervous system including endocannabinoid receptors which help modulate the levels of monoamines, perceptions of pleasure and pain, and mood.
Does Koi provide 3 rd party labs on their website?
Yes, and the labs confirm that the CBD hemp oil product contains therapeutic levels of CBD.
What’s the difference between CBD, hemp oil, and hemp extract?
CBD means cannabidiol. It is a single cannabinoid, the second most abundant in marijuana and the most abundant in low THC hemp. Hemp oil is hemp seed oil. It contains healthy fatty acids, but only very low levels of CBD. Hemp extract is hemp oil extracted from the whole plant, standardized for levels of CBD. Unscrupulous companies will try to confuse consumers, passing off hemp seed oil as CBD. Koi CBD is legit and upright with its CBD levels.
Koi CBD oil and other Koi products seem to be very well made. They post lab results for each batch and list the CBD concentrations per bottle and per serving. This is unique among companies. Most companies leave you to do the math yourself so that you don’t find out you will have to vape 3 full bottles to get one sufficient dose of CBD. With Koi vape, a normal amount can get you a therapeutic amount of CBD. And they also have tasty flavors and great label designs. So, it seems they really did their homework, used their in house lab, then sent it to a 3 rd party lab.
CBD oil disclaimers (please read, this is important):
General Medical Disclaimer
Leaf Expert and its employees and partners do not represent the medical establishment and our information is not a replacement for your doctor’s advice.
Food and Drug Administration Disclaimer
The use of CBD products with the exception of Epidiolex and Sativex has not been evaluated or approved by the FDA. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Drug Screening Disclaimer
While most CBD products claim to have little to no THC, it is theoretically possible to fail a drug test for THC. This can happen because some CBD products have been tested to have far more THC than represented on the label. Also, CBD is similar in structure to THC.
About CBD and CBD-A
How it Works (scientific research)
Koi’s products have cannabidiol as the main active ingredient. Cannabidiol is known to have many mechanisms of action. We list the receptors in the central nervous system which cannabidiol binds to below. These include cannabinoid receptors, serotonin receptors, and orphan receptors which are related to cannabinoid receptors by their structure. CBD also modulates opioid receptors by which it affects pain perception. These are not the only receptors cannabidiol may bind to or effect.
Cannabidiolic acid (CBDa) have been shown to have the following effects:
- Fighting nausea (Rock, Limebeer, & Parker, Effect of combined doses of Δ 9 -tetrahydrocannabinol (THC) and cannabidiol acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping, 2015)
- Breast Cancer growth inhibitor (Takeda, et al., 2012)
- Anxiety fighter (Pertwee, et al., 2018)
- Vomiting fighter (Bolognini, et al., 2013)
- Depression fighter (Hen-Shoval, et al., 2018)
- Diarrhea fighter (Cluny, et al., 2011)
- Studied for inflammatory pain (Rock, Limebeer, & Parker, Effect of cannabidiolic acid and ∆9-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain., 2018)
Cannabidiol (CBD) has been shown to have the following health benefits:
- Anti-cancer (Massi, Solinas, Cinquina, & Parolaro, 2013).
- Anti-infarction (Hayakawa, et al., 2004).
- Anti-psychotic (Iseger, Bossong, & Bossong, 2015).
- Anti-seizure activity, known about in 1973 (Izquierdo, Orsingher, & Berardi, 1973).
- Attenuates the adverse effects of THC (Henquet & Kuepper, 2010).
- Can fight memory loss caused by marijuana THC(Morgan, Schafer, Freeman, & Curran, 2010). This means that medical marijuana should be enriched with extra cannabidiol to avoid memory loss and psychotic effects
- Fights cerebral infarction by modulating serotonin (Mishima, et al., 2005).
- Fights migration of cancer cells (Kapoor, 2013).
- Fights myocardial ischemia-reperfusion injury (Durst, et al., 2007).
- Inhibiting angiogenesis feeds cancers (Solinas, et al., 2012).
- May fight autoimmune diabetes (Weiss, et al., Cannabidiol arrests the onset of autoimmune diabetes in NOD mice, 2008)
- May fight colon cancer (Aviello, et al., 2012).
- May fight neurodegeneration (Iuvone, Esposito, Filippis, Scuderi, & Steardo, 2009).
- May help in colitis (Borrelli, et al., 2009).
- May reduce immune system inflammatory responses (Kozela, et al., 2010).
- Modulates sleep (Murillo-Rodríguez, Millán-Aldaco, Palomero-Rivero, Mechoulam, & Drucker-Colín, 2006).
- Neuroprotective (Hampson, Grimaldi, Axelrod, & Wink, 1998).
- Prevents diabetes (Weiss, et al., Cannabidiol lowers the incidence of diabetes in non-obese diabetic mice, 2006)
- Reduces anxiety in the right doses (Fusar-Poli, et al., 2009).
- Vasorelaxation (Stanley, Hind, Tufarelli, & O’Sullivan, 2015).
- Wakefulness-promoting, modulation of circadian rhythms (Murillo-Rodríguez, et al., 2014).
Cannabidiol and cannabidiolic acid work by binding to various receptor targets throughout the central nervous system and the rest of the body. Acting at these receptor sites, it exerts influence on the metabolism of various neurotransmitter systems. It seems like ‘snake oil’ that one compound can have all the beneficial effects listed above; however, cannabinoid receptors exist throughout the nervous system and it is known that such a ubiquitous receptor must be involved in nearly everything the nervous system does, just like serotonin and dopamine receptors. Dopamine affects pleasure, but also pain. Anxiety and also relaxation. Heart contraction and blood pressure. All of these systems are integrated so cannabinoid receptors will indeed have effects on all of these systems and exogenous cannabinoids from plants can definitely have therapeutic effects that are extensive.
Mechanisms of action of CBD
- CB1 receptor agonist
- CB2 receptor agonist
- Glitazone receptor agonist
- GPR12 (inverse agonist)
- GPR3 (inverse agonist)
- GPR55 (antagonist) receptors
- GPR6 (inverse agonist)
- Inhibitor of fatty acid amide hydrolase, increasing levels of endogenous cannabinoids
- Serotonin 5-HT1A receptor partial agonist
- An allosteric modulator of mu and sigma opioid receptors (Kathmann, Flau, Redmer, Tränkle, & Schlicker, 2006)
The action of CBD and CBDa produces anti-inflammatory, anti-pain, and anti-seizure effects which can help relieve stress in a range of discomforting conditions.
Does CBD have any side effects?
CBD is unlikely to have many side effects under 300 mg daily. Above that dosage, one should consult a doctor.
Before we look at the side effects, let’s look at the safety. Consider these facts:
CBD Safety facts
- Does not induce changes in food intake
- Does not induce catalepsy
- CBD is non-toxic
- Does not affect physiological parameters such as:
- Heart rate
- Blood pressure
- Body temperature
- Does not affect gastrointestinal movement
- Does not alter the psychomotor function
- It does not alter psychological functions.
- Chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans.
(Bergamaschi, Queiroz, Zuardi, & Crippa, 2011)
Now, here are the side effects which have been reported:
Possible Negative Side Effects of CBD
- Inhibition of hepatic drug metabolism (possible drug interactions)
- Decreased fertilization capacity
- Decreased activities of p-glycoprotein and other drug transporters
- Alterations of in vitro cell viability
- Poor quality sleep
- Decreased appetite
- Changes in appetite
In general, CBD is safe and well-tolerated. Doses above 300 mg should have a doctor’s monitoring. Your doctor should manage drug interactions.