For those worried about THC showing up in their system, look for broad-spectrum oil or products that contain pure CBD isolate. Broad-spectrum oil, as opposed to full-spectrum oil, is refined to exclude the trace amounts of THC that may have been present in the hemp plant. Products with CBD isolate contain no THC or other plant-based cannabinoids. To find high-quality CBD, search for products that come with a certificate of analysis from a third-party testing lab to ensure that the information listed on the product label is accurate. Be careful not to confuse hemp seed oil or hemp oil, which seldom contain any CBD at all, with CBD oil. These products will provide a hearty dose of omega-3 fatty acids, but they won’t provide any potential pain-relieving or anti-anxiety effects.
You can consume CBD oil sublingually by placing a few drops of CBD under your tongue and rubbing it into the tissue there with your tongue or finger for at least 30 seconds to a minute before swallowing. This will allow the mucous membranes in your mouth to absorb the CBD, partially bypassing the digestive system and liver, for much quicker entry into the bloodstream. Effects may be felt within seconds. Just like when you ingest THC edibles though, you’ll get a second onset of effects a couple of hours later when the CBD that wasn’t absorbed sublingually makes it through your digestive system.
Studies show that when CBD compounds are metabolized by the liver, it undergoes what is called the “first pass effect,” where enzymes in the liver reduce CBD concentration before the remainder is finally sent to the bloodstream and circulated throughout the body.
How long does it take for CBD oil to work orally?
Bottom line: Ingesting CBD via a tincture or a CBD oil-infused edible will result in a longer onset (up to two hours) and possibly weaker effects.
The metabolic rate of the individual also has some sway over how long CBD stays in the system. The body’s metabolism determines the time needed to break down and synthesize compounds, which affects how long it takes the body to process and metabolize the cannabinoid.
The method of consumption plays a critical role in how long it will take to feel the effects of CBD. CBD is available in many different forms, and each has an influence on the onset time, among other factors.
Your body’s metabolism affects how long it takes to process and metabolize cannabinoids. Photo by: Gina Coleman/Weedmaps
Researchers have confirmed that CBD works against pain and inflammation , and they’re still finding new ways that it works in the body . They're also working to nail down the proper dose of topical CBD needed for pain relief. For example, the dose that brings relief to achy joints may be insufficient to effectively treat nerve damage in feet. While rubbing topical CBD onto the skin seems to work, researchers still need to figure out how much skin coverage is most effective. Some skin creams also contain menthols, which carry their own pain relief and anti-inflammatory properties, possibly masking any effect from the CBD itself.
Our knees ache, our backs hurt, our feet throb. Pain is one thing everybody wants gone. Unfortunately for chronic pain sufferers, many treatments come with unwanted side effects.
Topical CBD creams can treat pain, discomfort and inflammation. Here’s what science knows about how they work.
By the time you feel any annoying itch or prick of pain, CB1 and CB2 receptors on your skin cells have already fired off signals to help dampen those unpleasant vibes. These receptors — part of the body’s endocannabinoid system — spend their workdays responding to chemical messages that help our skin nurture a healthy balance. CBD cream bypasses the CB1 and CB2 receptors and heads straight for a neurotransmitter middleman that blocks signals for pain and itch by working through agents called anandamide and 2-AG.
Consumers aren’t waiting for clinical trials. But they need to remember, says Hurd, that slathering on creams can be risky, considering how the skin absorbs everything. Even topical CBD can react with oral medications.
Consumers need to be educated, as well, says Cather. She works to develop a trusting relationship with her patients, so that they’ll feel comfortable talking about using CBD. She also urges her patients to find companies that document what’s actually in the bottle or jar. Asking the company about their quality control, such as how often they document ingredients, can help also vet the product.