"When it comes to cannabis-based topicals for muscle soreness or other pain relief, there's absolutely no reason why it should be a big deal to try," he says.
The theoretical logic is that are a few different ways CBD could help regulate pain — by increasing your natural endocannabinoids, decreasing your inflammatory response, and desensitizing your pain receptors (although it's still unclear whether this stands when absorbed topically compared to orally).
What Is Hemp Pain Relief Cream?
Hemp creams for pain relief are typically is made from infusing high-quality cannabis flowers in some kind of quality oil-coconut or olive typically-which extracts the active compounds, either CBD, THC, or both depending on the type of hemp used. (Here's a guide to the difference between THC, CBD, cannabis, and hemp.) This oil is then blended with other therapeutic herbs, such as arnica or lemongrass essential oils, that are thought to also ease pain.
There is an argument to be made for the simple fact that science hasn't caught up to the trend (and laws) of cannabis yet. (Here's what research has to say about the potential benefits of CBD and cannabis so far.) And there are doubtlessly researchers testing the efficacy of CBD creams for pain relief as we speak.
Biology lesson aside, all of this has yet to be proven in scientific studies on humans.
More recent research suggests that many of CBD’s effects may occur outside of CB receptors, Jordan Tishler, M.D., medical cannabis expert at InhaleMD in Boston, tells SELF. In fact, according to a recent review published in Molecules, CBD may have effects on some serotonin receptors (known to play a role in depression and anxiety), adenosine receptors (one of the neurological targets for caffeine), and even TRPV-1 receptors (more commonly associated with taste and the sensation of spiciness).
The first thing to be aware of is the amount of CBD that a product claims to contain. Because the studies we have about CBD and pain all looked at systemic administration rather than truly local, we don’t really know what the correct dose would be when applied locally. It’s tempting to go for the highest amount you can find, but it’s really up to you since we don’t even know where to start.
What is CBD?
Two other common reasons people take CBD are to manage anxiety and sleep issues, two things we know can contribute to pain, Boehnke says. If you're dealing those kinds of issues in addition to pain, any reduction in pain you feel could be an indirect effect of it helping you manage anxiety or sleep. (But those are still unlikely to be affected by a topical formulation.)
The only thing that comes close is a Phase 2 clinical trial using a proprietary CBD transdermal gel (meaning it’s meant to go through the skin into the bloodstream) in 320 patients with knee osteoarthritis over 12 weeks, which has not been peer-reviewed to date. Unfortunately, in almost all of the study’s measures of pain, those who received CBD didn’t have statistically different scores from those who got placebo. But “they found some reductions in pain and improvements in physical function,” Boehnke says.
When the National Academies of Sciences, Medicine, and Engineering evaluated decades of cannabis research, they concluded that "in adults with chronic pain, patients who were treated with cannabis or cannabinoids are more likely to experience a clinically significant reduction in pain symptoms."