One of the biggest concerns that consumers face when purchasing CBD products is the lack of FDA regulation.
It is also important to note that CBD is available in isolate (only CBD), broad-spectrum (contains other cannabinoids but not THC), and full-spectrum (contains other cannabinoids, including THC).
Cannabidiol is available in several different forms, although only those that are ingested are likely to produce any antidepressant-like effects or other mental health benefits. It may be taken orally as an oil, spray, or capsule. CBD may also be added to edible products including beverages, candies, or chewable gummies.
CBD, on the other hand, is purported to have a wide range of health benefits without these psychoactive effects. Some research suggests that CBD has antidepressant-like effects, which means it may hold promise in alleviating symptoms of depression.
Other studies suggest that CBD may help alleviate symptoms of depression by interacting with serotonin receptors in the brain. Serotonin is a neurotransmitter that plays a role in a range of functions in the body including the regulation of mood. It may help contribute to feelings of happiness and well-being. It is also often implicated in the onset of depression and many types of antidepressant drugs work by increasing serotonin levels in the brain.
CBD holds promise, but that does not mean that you should turn to cannabidiol products over traditional treatments for depression.
CBD products are not subject to regulation because they are marketed as supplements, which means that you don’t know if you are really getting what is described on the label. Because these products are not regulated, you have no way of knowing for sure what you are getting in terms of purity, safety, and dosage.
Major depressive disorder is the leading cause of disability among Americans aged 15 to 44. It affects approximately 7% of Americans per year, as well as more than 300 million people worldwide. While this condition can develop at any age, the average onset is 32 years old; it is more prevalent in women than in men.
A growing body of research suggests that deficiencies in the endocannabinoid system (ECS) may produce depressive responses. Clinical and preclinical data suggest that cannabinoid receptor signaling may be an ideal target for developing new pharmacotherapy options for both anxiety and mood disorders.
“There is scientific evidence to suggest that CBD has antidepressant-like effects,” Rosalia Yoon, Ph.D., a Research Scientist for Apollo Cannabis Clinics in Ontario, Canada, told Weedmaps. “From a neurophysiological perspective, the endocannabinoid system (ECS) is known to modulate functions associated with cognition, mood, sleep, pain, reward, and motivation; and decreased ECS activity has been postulated to account for some of the symptomatology associated with depression, such as low mood, anhedonia, anxiety, and decreased pain tolerance.”
“For example, one middle-aged man who found the side effects of antidepressants to be intolerable, experiencing insomnia and decreased sexual function, started using low doses of a 4:1 CBD:THC tincture. He self-reported a 90% improvement of his depression symptoms with no side effects,” she said.
Dr. Bonni Goldstein, medical director of California-based Canna-Centers and a subject matter adviser for Weedmaps, said she knows of anecdotes of people who said they used CBD to treat depression. “Preclinical animal data reports that CBD can have antidepressant effects. There are many anecdotal reports of patients using CBD successfully to treat depression but clinical trials in humans are lacking,” said Goldstein, who is also author of “Cannabis Revealed.”
Cannabidiol, or CBD, is a natural compound that has gained popularity in recent years. Here are some frequently asked questions about CBD answered by two mental health professionals who are working in this area:
If there are adequate safety studies of a product, it would be considered safe. However, the CBD products flooding the market are not likely to have undergone any safety testing. In fact, the FDA has issued several warning letters to firms that market unapproved new drugs that allegedly contain cannabidiol. As part of these actions, the FDA has tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to contain. It is important to note that these products are not approved by FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease. Consumers should beware purchasing and using any such products.
7. Are there pricing regulations for CBD?
6. Is CBD FDA approved and can doctors prescribe it?
5. Is there current research in the US for CBD? Are other countries using CBD?