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How one molecule from the cannabis plant came to be seen as a therapeutic cure-all.

Nor are most drugs completely free of side effects. In the standard drug-approval process, observed side effects are noted on the packaging. If new ones show up after F.D.A. approval, they can be added later. As Ken Mackie, from Indiana University, told me, there’s no mechanism to do this in the vernacular movement, no central repository of interactions and side effects.

Hurd’s research, replicated by others, indicates that CBD might help recovering opioid addicts avoid relapse, perhaps the greatest challenge they face. She’s not sure why but suspects that by reducing anxiety and craving — major triggers of relapse — CBD helps patients stay the course. And because it’s not habit-forming, like other anti-anxiety medications, CBD might be a badly needed new weapon with which to fight an epidemic that claims more than 130 lives daily in the United States.

When scientists at the French pharmaceutical company Sanofi-Aventis (now Sanofi) understood that THC could whet a user’s appetite, they created a weight-loss drug that blocked CB1 receptors, hoping to suppress appetite. Rimonabant was first released in Europe in 2006. Two years later, regulators pulled it from the marketplace because of its severe side effects, including depression and suicidal behavior. The episode seems to exemplify endocannabinoids’ importance to our sense of well-being and the difficulty of manipulating them therapeutically. Attempts to increase native cannabinoids with synthetic drugs have fared no better. In 2016, French scientists halted a study of a drug designed to boost endocannabinoids. For reasons that remain unclear, six patients who took the medicine, meant to treat pain, were hospitalized. One died.

Endocannabinoids help regulate immune activity, appetite and memory formation, among many other functions. (Heavy marijuana use is associated with memory deficits, possibly because THC short-circuits the formation of memories.) “Perhaps no other signaling system discovered during the past 15 years is raising as many expectations for the development of new therapeutic drugs,” Vincenzo Di Marzo, an endocannabinoid researcher at the National Research Council in Naples, Italy, wrote in 2008, in the journal Nature Reviews Drug Discovery. But realizing such medical benefits has proved trickier than once imagined.

The team behind American comfort food restaurant, Dirty Bones, are excited to announce that its second site in Soho will be open from Monday 28th September. The original restaurant, which opened in Kensington in 2014, will see its sister site take a space on the top floor of Kingly Court’s vibrant courtyard.
Dirty Bones Carnaby, seating 65, will serve a menu of American comfort food classics with a twist such as: The Mac Daddy Burger (6oz house burger topped with pulled beef short rib, mac ‘n’ cheese, Dirty Bones barbecue sauce and Dirty Bones pickles); BBQ Fried Chicken (free range crispy fried chicken thighs and drumsticks in Dirty Bones bourbon and marshmallow barbecue sauce); and the Dirty Dog (Dirty Bones barbecue pulled pork, crispy bacon, jalapeno cheese sauce, crispy shallots).
Diners will also be able to enjoy a new weekend brunch menu with indulgent dishes such as: the Benedict Burger (6oz house burger, topped with poached egg and black treacle bacon, smothered in Dirty Bones hollandaise sauce); Steak & Eggs (30 day age flat iron steak, chargrilled and served with two free range fried eggs and Dirty Bones smoked ketchup); and Short rib & cheese toastie (triple stack toastie of beef rib, charred gherkin, English mustard, taleggio and cheddar on sourdough). These decadent dishes will run alongside a bottomless £15 Prosecco offering.
From the 5th October, all guests will be invited to take part in a game of Dirty Bonopoly, a playful take on the classic board game, which will give diners the chance to win special prizes. Each table will be offered one roll of the dice, and will be rewarded with offers for both the Carnaby and Kensington restaurants such as 50% off the bill or a round of drinks on the house. However, if diners land on the ‘go to jail’ square, they risk a devilish forfeit. The game will be available to play at both Carnaby and Kensington.
The restaurant will feature a lively bar area, serving playful cocktails such as: the Dirty Mary (Finlandia vodka, tomato, orange, lemon and pickle juice, fresh mint, chilli sauce and a sour cream Pringle rim); and Mutt’s Nuts (Woodford Reserve, cinnamon and vanilla infused maple syrup, Angostura bitters, lemon and apple juices). The restaurant will also serve a great selection of craft beer. The restaurant will also offer its renowned Dirty Hour, serving two for one cocktails from 3-7pm every weekday.
As in Kensington, the Dirty Bones interior will be retro in style, with a pinball machine welcome desk plus other quirky surprises. The Dirty Bones playlist will encompass classic hip hop and old skool gems.