However, a double-blind study found healthy volunteers administered CBD had little to no change in their emotional reaction to unpleasant images or words, compared to the placebo group. “If it’s a calming drug, it should change their responses to the stimuli,” said Harriet de Wit, co-author of the study and a professor in the University of Chicago’s department of psychiatry and behavioral neuroscience. “But it didn’t.”
Last year, the F.D.A. approved Epidiolex, a purified CBD extract, to treat rare seizure disorders in patients 2 years or older after three randomized, double-blind and placebo-controlled clinical trials with 516 patients that showed the drug, taken along with other medications, helped to reduce seizures. These types of studies are the gold standard in medicine, in which participants are divided by chance, and neither the subject nor the investigator knows which group is taking the placebo or the medication.
Sleep can be disrupted for many reasons, including depression. Rodents seemed to adapt better to stressful conditions and exhibited less depressive-like behavior after taking CBD, according to a review in Journal of Chemical Neuroanatomy. “Surprisingly, CBD seems to act faster than conventional antidepressants,” wrote one of the authors of a new review, Sâmia Joca, a fellow at the Aarhus Institute of Advanced Studies in Denmark and an associate professor at the University of São Paulo in Brazil, in an email interview. Of course, it’s difficult to detect depression in animals, but the studies that Ms. Joca and her colleagues reviewed suggested that in models of chronic stress exposure, the mice and rats treated with CBD were more resilient.
Does CBD work?
A recent chart review of 72 psychiatric patients treated with CBD found that anxiety improved, but not sleep. “Over all, we did not find that it panned out as a useful treatment for sleep,” said Dr. Scott Shannon, assistant clinical professor of psychiatry at the University of Colorado, Denver and the lead author of the review in The Permanente Journal.
This year, 1,090 people have contacted poison control centers about CBD, according to the American Association of Poison Control Centers. Over a third are estimated to have received medical attention, and 46 were admitted into a critical care unit, possibly because of exposure to other products, or drug interactions. In addition, concern over 318 animals poured into the American Society for the Prevention of Cruelty to Animals’ Animal Poison Control Center.
Earlier research found fewer than a third of 84 products studied contained the amount of CBD on their labels. Some users of CBD have also failed drug tests when the product contained more THC than indicated.
Many soldiers return home haunted by war and PTSD and often avoid certain activities, places or people associated with their traumatic events. The Department of Veterans Affairs is funding its first study on CBD, pairing it with psychotherapy.
The Original Recipe creates the quintessential Bloody Mary. With fresh horseradish (off the root!), hand chopped garlic and onions, dill, and lemon juice, you would be hard-pressed to find a more complete Bloody mix outside of your own kitchen. We never skimp on any ingredients, because we have designed this mix for the true Bloody Mary connoisseur.
For the perfect Freshies Bloody: Combine 2 oz. of Vodka & 6 oz. of Freshies Bloody Mary Mix over ice in a pint glass. Garnish with a fresh lime wedge and a Freshies Spicy Green Bean. Enjoy!
Freshies best-selling cocktail mixers just got a bit more interesting! Introducing our new CBD Bloody Mary with 100mg of CBD and “broad spectrum” hemp extract. It’s the same recipe we all know and love, but with a cannabis twist!
Also contains 100mg of CBD and “broad spectrum” hemp extract. Broad spectrum extract means that there are a wide range of other compounds that are found in the hemp plant, yet there is 0.00% THC. So it promotes the “entourage effect” and includes other potentially beneficial cannabinoids such as CBG, CBC, CBN, and more.
Ingredients: Water, tomatoes, worcestershire (distilled vinegar, water, molasses, corn syrup, salt, caramel color, garlic powder, sugar, spices, tamarinds, natural flavor), fresh onion, fresh horseradish, celery salt (celery, salt), fresh garlic, fresh dill, fresh lemon juice, hot sauce (vinegar, red pepper, salt), dijon mustard (black mustard seeds, vinegar, white wine, salt, spices) and black pepper.