Ultrasonic cavitation is a very effective emulsification method to prepare superior emulsions in the nano range. The sonication of emulsions with turbidities (micro-emulsions, approx. 150 to 100nm) makes them translucent or clear and transparent, because it reduces the CBD droplet size to diminutive droplets in the range of approx. 10nm. This increases the emulsion stability significantly. Ultrasonically produced emulsions are often self-stable without addition of an emulsifier or surfactant.
For cannabis oil, nano emulsification improves cannabinoids absorption (bioavailability) and produces a more profound effect. Therefore lower cannabis product doses can give you the same effects.
Cannabis oil emulsions are suspensions of micron-size or nano-size cannabinoids for cannabis-, hemp-, THC- or CBD-based products such as tinctures, capsules, lotions, and e-cigarette vape cartridges. Cannabinoids such as THC, CBD etc. are lipophilic (= hydrophobic). Therefore they require intense shear to disperse the cannabinoid in water-based formulations. Cannabinoids are not soluble in water, but they show a good solubility in non-polar solvents such as oils and fats. It requires a suitable emulsification technique to overcome the immiscibility of cannabinoids in water. Intense ultrasonic cavitation is well-known and well-established technique to produce fine-sized, stable emulsions (o/w, w/o, w/o/w, o/w/o, micro- and nanoemulsions).
You can produce a CBD nanoemulsion in batch or continuous mode using an ultrasonic emulsification machine. Hielscher ultrasonic homogenizers are powerful emulsifiers to produce stable CBD nano-emulsions. The ultrasonic production of cannabis oil emulsions (o/w) is an easy and fast procedure, which convinces by optimum results.
Liposomal Emulsions of CBD
Ultrasonification is the preffered method to produce liposomal CDB or liposomal THC as pharmaceutical and cosmetic vesicles. Liposomes are lipid-based nanocarriers for active drug components, which improve the bioavailability and therapeutic effects of the active substances such as CBD or THC. Since cannabinoids are really delicate molecules, they are prone to degradation by oxidization as well as to degradation by different enzymes. Nano-encapsulation of CBD or THC in liposomes, prevents the degradation of the cannabinoids. Sonication can effectively encapsulate the cannabinoids into liposomes.
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In order to produce long-term stable oil-in-water (o/w) nanoemulsions, it is necessary to use a suitable surfactant or to form liposomes that encapsulate the lipophilic bioactive compounds into a carrier oil. For cannabis oil, the carrier oil should have food quality and it should not interfere with appearance, taste, or stability of the final product. Coconut oil (MCT) and olive oil are good carrier oils for cannabinoids. Carrier oils are a very important factor to create a physicochemically stable emulsion since they may help to prevent the emulsion against Ostwald ripening. The Ostwald ripening is the driving force which destabilizes an emulsion by droplet coarsening. Long chain triglyceride nanoemulsions are long-term stable against Ostwald ripening. Olive oil and coconut oil contain long chain triglycerides, so that both, olive and coconut oil are a suitable carrier oils to THC or CBD.
For larger scale setups use a Hielscher InsertMPC48 to inject the CBD oil directly into the cavitational area under the ultrasonic sonotrode.
In order to prepare stable CBD nano-emulsions, a mix of Polysorbate 80 and Lecithin works very well. There is no need to buy overpriced pre-mixes as both additives are easily available in food-grade.
When you ingest cannabinoids, whether they are hemp or cannabis-derived, it may take some time for the cell membranes in your body to absorb them. The addition of sunflower lecithin helps your cell membranes accept and absorb more of the cannabinoids.
Your body’s natural metabolism also plays a vital role in the acceptance of CBD products including sunflower lecithin. The faster your metabolism is, the sooner you will notice that the oil or capsule is working. If you have a slower metabolism and need your full-spectrum hemp CBD to start working faster, exercise is the answer. Don’t overdo it though, you only want to raise your heart rate enough to jumpstart your metabolism to absorb the cannabinoids faster.
One last notable benefit to mention is a potential prevention of hardening of the arteries, so it may help prevent strokes, heart attacks and other heart-related issues.
Why your Full-Spectrum CBD May Seem More Potent