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This is every woman’s dream come true. High heels are just not made the way they used to be—stilettos these days are narrower, higher, and pointier. Remember: Louboutin does not concern himself with the comfort of his designs. (He said so himself in the documentary and several other news outlets.) Gone are the days of the sensible heels our grandmothers wore. But alas, sky–high footwear is a necessary evil. So Lord Jones, the wildly–popular CBD company, collaborated with Tamara Mellon to help ease that discomfort. Just dab a little solution onto your feet and wait for your skin to absorb the formula before putting on your four–inch torture device.

I’m no spring chicken and the occasional bout of soreness is now a fact of life.

Here’s what I have found most effective over the years.

ONYX + ROSE BROAD SPECTRUM CBD BLISS BALM (500MG; $54)

“I have treated many patients with chronic conditions with full spectrum CBD and attained great results,” Dr. Amin says. “I also believe the public needs to understand that CBD works in conjunction with THC. Usually this requires at least 3–5% THC to work for serious forms of pain and more chronic medical conditions. I have patients come in with chronic and severe pain expecting to have their pain alleviated with just CBD. Although CBD works well for pain, in many situations patients with severe pain need to have some THC. [The cannabinoids] work synergistically to help ease severe pain.”

This high–dose balm seems to be a crowd favorite, certainly in my household. The jar itself contains two ounces of product. It doesn’t seem like much—But because the consistency of the cream is particularly smooth and spreadable, it glides easily onto the skin and covers more real estate. In terms of relief, you can expect gradual relaxation of the muscles—especially if you’re prone to spasms or simply incredibly tight.

So recovery is a big deal. And personally, I’m all about CBD (a.k.a cannabidiol)—the non-psychoactive compound in cannabis. It’s been having a moment these past few years, making appearances in all sorts of wellness and beauty products—from CBD edibles, to capsules, to transdermal patches, and beyond. But make no mistake. It’s not the passing health trend that activated charcoal and golden milk used to be.

Baskin has a lower–dose formula that clocks in at 150mg CBD that costs $20 less. But I say, Go big or go home. Invest in the higher dose if you want real relief all over: It’s meant to be used all over the body versus its cousin, which was specifically created for smaller targeted areas. Beyond that, you can always use the 400mg cream the way you see fit: Nobody is going to stop you if you want to use it only in specific pain points.

Challenge: Oral administration

Botanical cannabinoids may create significant challenges for drug manufacturers because of the natural resources and security measures required to grow and harvest Cannabis .

Challenge: Botanically derived cannabinoids

Addressing Limitations of Current Treatments

Zygel is the first and only pharmaceutically-produced CBD, a non-euphoric cannabinoid, formulated as a patent-protected permeation-enhanced gel for transdermal delivery through the skin and into the circulatory system. Zygel is being developed for patients suffering from FXS, ASD in pediatric patients, 22q, and a heterogeneous group of rare and ultra-rare epilepsies known as developmental and epileptic encephalopathies (DEE).

Oral administration can lead to limitations in safety and efficacy including gastrointestinal side effects like nausea, vomiting and diarrhea, low bioavailability, inconsistent plasma levels and significant first-pass liver metabolism. First-pass liver metabolism refers to the process by which the liver breaks down drugs ingested directly or indirectly through the gastrointestinal system, such as through oral or oral-mucosal delivery methods, allowing only a small amount of drug to be absorbed into the circulatory system.

Potential Benefit of Zygel:
Zygel is a unique permeation-enhanced CBD transdermal gel. Transdermal therapeutics are applied locally and absorbed through the skin directly into the systemic circulation, resulting in a lower incidence of gastrointestinal side effects, and avoidance of first-pass liver metabolism, which potentially enables lower dosage levels of active pharmaceutical ingredients and rapid, reliable absorption with increased bioavailability. Other potential benefits of transdermal delivery compared with oral administration may include fewer drug-drug interactions.

Zygel is an experimental treatment. This means that it is not approved by government regulatory bodies, including the United States Food and Drug Administration (FDA) and other agencies and must be tested to see if it is an effective and safe treatment.