Cannabinoids, both endogenous and exogenous, bind to endocannabinoid receptors attached to cells. These include cannabinoid 1 and cannabinoid 2 receptors. This binding action stimulates different cell responses that influence pain signaling pathways.
In this article, we discuss how CBD products may help relieve chronic pain. We also provide a list of potentially effective CBD products that have undergone extensive third-party testing for safety.
CBD is one of several cannabinoids that are naturally present in the cannabis plant. There are a vast range of CBD products, including oils, tinctures, balms, and candy, all of which may help people who are experiencing physical pain.
CBD does not bind very well to endocannabinoid receptors. However, it may interact with neurological receptors in the spinal cord that suppress chronic inflammatory pain, as one study on mice found. CBD may also strengthen the effects of AEA, an endogenous cannabinoid that reduces pain.
The ECS consists of complex cell signaling pathways in the central nervous system and immune system.
CBD and other cannabinoids act on cannabinoid receptors found throughout the body. These receptors, combined with naturally occurring cannabinoids, make up the endocannabinoid system (ECS).
Six of the seven participants reported improvements in pain. One of the participants experienced more pain at higher CBD doses but achieved the best pain control at lower CBD doses.
CBD capsules make dosing easier than CBD gummies or vapes because you know how much CBD is in each capsule. This is important if you're dosing regularly for chronic pain or anxiety, and want to maintain a consistent level of botanical extract in your body.
Based on the above criteria, here are the best CBD capsules:
There's no one "correct" amount of CBD you should take because it varies from person to person. If you're new to CBD, it's best to start at the lower end of the spectrum (take one capsule at a time) and gradually work your way up as needed.
Best Full Spectrum: Cornbread Hemp Capsules
With all of the above factors in mind, here are the top CBD capsules based on customer reviews, price, and source of the hemp. Each product has also been reviewed by a third-party laboratory for label accuracy and potential contaminants, including heavy metals, residual solvents, and pesticides.
The Charlotte’s Web product line is known for its full spectrum CBD extracts, which come from American-grown hemp plants. This particular product is noteworthy for its array of naturally occurring phytocannabinoids, terpenes, flavonoids, and essential fatty acids. If you’re in the market for a strong CBD oil supplement, the 25 milligram capsules are a good option. If you want something less potent, Charlotte’s Web also offers other capsules with 15 milligrams of CBD in each (with a lower price per bottle).
Prima CBD pills are designed to help combat stress and target issues at their source. Prima holds itself to the highest social and environmental standards and is a certified B Corp. Each of these vegan softgels contain 25 milligrams of CBD, which makes them a subtle, daily dose of hemp extract.
Some people prefer to completely avoid THC when it comes to their hemp products, especially if they are concerned with taking a drug test. So if you’re shopping for an isolate CBD pill, the Medterra gel capsules are worth a try. These capsules, which have a 4.5-star rating, are made with 99.6% pure CBD derived from high-quality Kentucky hemp plants, and the products are completely devoid of THC. A bit of MCT oil is added to provide a smooth liquid suspension, and customers have the option to choose between two strengths: 25 or 50 milligrams per capsule.