In general, it’s best to start with a lower dosage. In fact, studies of CBD for other disorders such as migraine suggest that a lower dose may be more effective.
Children with autism grow and learn every day, simply because they are maturing. As a result, there is no simple way to determine whether a change in behavior or an increase in skills is due to a particular treatment or to ordinary maturation. This reality makes it very easy to see a change in behaviors and inaccurately attribute them to the newest treatment you’ve tried. By far, the best way to know whether a particular treatment is truly effective is to be rigorous about evaluating your child before and after its use.
CBD comes in many forms and at many dosage levels. Oils taste somewhat bitter, which is why many people prefer chewable candy-like options; of course, it’s important to keep candy-like drugs and supplements out of the reach of children.
Before Trying CBD
Currently, there is some evidence that CBD can help to alleviate specific symptoms and improve behavior in children and adults on the autism spectrum, but research into the safety and efficacy of CBD is in its earliest stages.
In addition (and perhaps as a result), they also saw significant improvements in social communication, sleep, and self-injury (a small percentage, however, worsened with treatment). A tremendous bonus is the fact that there were few side effects, and those that did appear (sleepiness and change in appetite) were mild.
“In 2014, The Ministry of Health began providing licenses for the treatment of children with epilepsy. After seeing the results of cannabis treatment on symptoms like anxiety, aggression, panic, tantrums and self-injurious behavior, in children with epilepsy, parents of severely autistic children turned to medical cannabis for relief.”
Cannabidiol , sometimes called CBD, is a chemical compound found in the cannabis plant. Since it does not include THC, the psychoactive component of cannabis, CBD does not induce a “high.” It can, however, help to reduce anxiety and lower stress levels—symptoms that are common among people with autism.
Depending on the strain of the plant and the processing methods used, these products contain varying levels of active ingredients, including tetrahydrocannabinol (THC) — responsible for the ‘high’ associated with marijuana — and cannabidiol (CBD), which is minimally psychoactive. Much of the research on medical applications focuses on CBD. There are also more than 500 other compounds in marijuana that may affect people’s behavior and cognition 1 .
Cannabis may have effects that go beyond the cannabinoid receptors, too. Mice that ingested CBD over extended periods of time displayed changes to DNA methylation in sections of the genome associated with autism, a 2020 study showed 10 . The researchers suggested that epigenetic changes may be at least partly responsible for CBD’s behavioral effects, though they did not directly examine the mice’s behavior.
Over the past decade, autistic people and their families have increasingly experimented with medical marijuana and products derived from it. Many hope these compounds will alleviate a range of autism-related traits and problems. But scientists are still in the early stages of rigorous research into marijuana’s safety and effectiveness, which means that people who pursue it as treatment must rely mostly on anecdotal information from friends and message boards for guidance.
Both types of cannabinoid receptors are located in neurons in the brain and throughout the body. The brain contains more CB1 than CB2 receptors, and the activation of each receptor type affects a range of ion channels and proteins involved in cell signaling 3 . The ultimate effects of cannabinoid receptor activation depend on which body system they belong to. For instance, the activation of CB1 receptors in the brain can either increase or decrease neuron excitability, depending on which kind of neuron a cannabinoid binds to; activation of CB2 receptors in the digestive system can decrease inflammation 4,5 .
The actual potency of CBD products varies widely from their advertised concentrations, according to a 2017 study in JAMA, and some products contain more than the legal limit of THC — potentially enough to cause intoxication, especially in children 12 . Less than one-third of the products tested contained within 10 percent of the advertised CBD concentration, and THC was detected in about 21 percent of samples.