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cbd oil as a topical.for skin cancer

143. Bai J, Zheng Y, Wang G, Liu P. Protective effect of D-limonene against oxidative stress-induced cell damage in human lens epithelial cells via the p38 pathway. Oxid Med Cell Longev. 2016;2016.

112. Telek A, Bíró T, Bodó E, et al. Inhibition of human hair follicle growth by endo- and exocannabinoids. FASEB J. 2007;21(13):3534–3541. doi:10.1096/fj.06-7689com

26. Petrocellis LD, Cascio MG, Marzo VD. The endocannabinoid system: a general view and latest additions. Br J Pharmacol. 2004;141(5):765–774.

Cutaneous Malignancies

7. Sugawara K, Biro T, Tsuruta D, et al. Endocannabinoids limit excessive mast cell maturation and activation in human skin. J Allergy Clin Immunol. 2012;129(3):726–738.e728.

63. Zengin G, Menghini L, Di Sotto A, et al. Chromatographic analyses, in vitro biological activities, and cytotoxicity of cannabis sativa l. Essential oil: A multidisciplinary study. Molecules. 2018;23(12):3266.

We speculate that Hemp seed extract or hemp EO could also have potential for treating acne vulgaris because of its anti-lipogenic, anti-proliferative, anti-inflammatory, and anti-microbial, properties, which may target similar or independent mechanisms than that of CBD. Unfortunately, no large-scale human trials have investigated the role of CBD for the management of acne. Larger studies will help to understand how CBD may impact acne at the clinical level.

133. Appendino G, Gibbons S, Giana A, et al. Antibacterial cannabinoids from Cannabis sativa: a structure− activity study. J Nat Prod. 2008;71(8):1427–1430. doi:10.1021/np8002673

Addendum September 2016:

The good news is that not all skin cancers need surgery – some may be suitable for treatment with cream, especially in older patients and in many cases, the treatment is fully funded.

The proposed mechanisms of action of cannabis oil are plausible but unfortunately that does not make it safe or effective.

Cannabinoids do bind to receptors which are present in many cells and there is some evidence in highly controlled laboratory circumstances that cannabinoids may inhibit some cancers. Sadly, there is also evidence that it may actually accelerate growth in others. There have been no useful trials in living humans and animal trials are not conclusive. The link at the end of this article gives more information and is maintained by the Uk Cancer Society so may be seen as a trusted and valid reference.

It is important to note that some of the cancers being illustrated as treated with the oil are of a type that can spread and potentially kill the patient. We feel that using a totally untrialled medication like cannabis oil in such circumstances is very unwise.

Never having been asked this before, a thorough review of the available literature was carried out, but sadly there have been absolutely no published clinical trials to date so it is impossible to recommend this treatment.

We feel that it is important to point out that there is also good evidence that smoking cannabis (as opposed to a topical application) significantly increases the risk of lung and head and neck cancer, whether or not it is used in combination with tobacco. Whilst there may in the future be a place for medicinal use of cannabinoids, at present the evidence very strongly suggests that in almost all cases the side effects outweigh the benefits.