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CBD oil may also increase liver enzymes (a marker of liver inflammation). People with liver disease should use CBD oil with caution, ideally under the care of a doctor who can regularly check blood liver enzyme levels.

There is some evidence that CBD interacts with seizure medications such as Onfi (clobazam) and boosts their concentration in the blood. Further research is needed.

Many of these interactions are mild and require no adjustment to treatment. Others may require a drug substitution or the separation of doses by several hours.

Possible Side Effects

To use CBD oil, place one or more drops under the tongue and hold the dose there for 30 to 60 seconds without swallowing. Capsules and gummies are easier to dose, although they tend to be more costly. CBD sublingual sprays are available as well.

CBD’s exact mechanism of action is unclear. Unlike THC, CBD has a relatively low affinity for cannabinoid receptors in the brain. These are the molecules to which THC binds to elicit its psychoactive effects.

The findings suggest that CBD oil may be a suitable complementary therapy for people whose hypertension is complicated by stress and anxiety. However, there is no evidence that CBD oil can treat hypertension on its own or prevent hypertension in people at risk. While stress is known to complicate high blood pressure, it cannot cause hypertension.

CBD is the short name for cannabidiol, one of the two chemicals—among the dozens in cannabis—that have the most health benefits. The other, tetrahydrocannabinol (THC), produces the psychoactive effects described as being “high.” CBD oil generally does not contain THC, although some trace amounts may be present in products sold in certain states.