This is the one side effect of concern, and it only applies when taking a hepatic drug (metabolized in the liver).
This is just like taking an over-the-counter medication in pill form, so most have no issues waiting up to an hour.
CBD is a known inhibitor of CYP450 enzymes
We always recommend using our CBD dosage calculator whenever changing your CBD dosage.
This is one of the most asked questions we get, and we have an easy answer.
This is the one side effect of concern and it only applies when taking a prescription drug metabolized in the liver. CBD inhibits CYP450 enzymes. Kale and turmeric can inhibit these same enzymes, along with grapefruit , red wine, and St John’s Wort.
One form may be more effective for you than others, so the fact that you might not find edibles or topicals effective does not mean that CBD doesn’t necessarily work for you. If you want to control your dosage levels, however, tinctures are the most recommended form.
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Studies find that it is possible that weight may play a major role in terms of CBD Dosage… Currently, there’s are two schools of thought in regards to CBD Calculation when it comes to weight. One group considers weight to be irrelevant being that CBD acts mainly on the cannabinoid receptors which are found primarily in the brain and spinal cord which are nearly identical in every person… Never the less, the other school of thought considers the following: CBD does encounter other bodily tissue prior to reaching the endocannabinoid system. The process, speed, and turnaround with which it travels and accumulates varies based on body weight and mass… Hence, based on our own collected data we tend to agree with the latter. In the study of obesity and pharmocokinetics (which involves body weight to medicinal absorption) science considers the following factors to affect absorption in relation to weight:
How does weight affect CBD Dosage?
The Food and Drug Administration hasn’t evaluated our statements.
DISTRIBUTION RATE – The rate at which CBD may be distributed through the various organs in the body. Being that various parts of the body have receptors that accept cannabinoids at different rates, the distribution of cannabinoids plays a role in its’ absorption.
T he typical method of finding a possible CBD dosage is to start off with a minuscule amount. For instance, users might start off with 3-5 mg dosage for the first week. If the user experiences no change, they might increase to 10 mg, and continue increasing it bit by bit until they find it subjectively effective and consistent in providing possible relief.
ABSORPTION RATE – The rate at which CBD may be absorbed through the body’s endocannabinoid system.