The human body has two receptors for cannabinoids: CB1 and CB2. Most CB1 receptors are found in the brain, which deal with coordination, movement and appetite. CB2 receptors are more commonly found in the immune system and affect pain and inflammation.
A 2015 study of CBD oil effects in humans concluded that CBD is generally well-tolerated and considered safe. However, it can cause certain adverse reactions such as diarrhea and stomach ache. 
Cannabis pills containing only CBD and not THC were sold legally for the first time in Europe in 2015.
How does CBD oil work?
Studies have also shown that CBD oil has benefits for people with epilepsy, mental health disorders such as anxiety and depression, and helping people quit smoking. 
Meanwhile, in 2016, University of Nottingham researchers showed that CBD in combination with another cannabis compound called tetrahydrocannabivarin (THCV), helped lower blood sugar levels and increase insulin production in people with type 2 diabetes. 
Growing research is demonstrating how CBD oil can provide pain relief for people with certain health complications, without the addition of any mind-altering effects.
Cannabidiol (CBD) oil is derived from the CBD compound which is found in cannabis, and has been associated with having a number of potential therapeutic uses, including for diabetes.
DeLuca states that there is good reason to believe CBD may benefit patients with diabetes. “Diabetes is an autoimmune disease and CBD is generally and particularly well-suited for the symptoms of autoimmune disease: chronic pain, inflammation, anxiety, and neuropathy.”
As many as two out of every five Americans will develop Type 2 diabetes during their lifetime. Both Type 1 and Type 2 diabetes are chronic disorders that stem from the body creating insufficient insulin or becoming resistant to insulin. Insulin is a hormone produced by the pancreas that helps with the storage and usage of glucose, a sugar that supplies cells with energy.
In the meantime, DeLuca discourages individuals from using CBD as a first-line treatment until sufficient human research has been conducted, but she believes CBD could be included as an adjunct treatment.
A 2010 preclinical study published in the Journal of the American College of Cardiology noted that not only did CBD help to reduce inflammation in a diabetic population of mice, but it also helped to lower the likelihood of cardiovascular disorders that can occur among diabetics.
On a Reddit thread discussing CBD oil for diabetes, one contributor was positive about the effects of CBD combined with regular medication. “I’m a Type II diabetic, controlled by oral meds and diet. I’ve been taking CBD caps twice daily and my AM sugar has dropped 15-20 points.”
For other people living with diabetes, however, the benefits of CBD are debatable. Another Reddit contributor observed, “I’ve had my first try of it over the last few days and I’m honestly unsure what all of the fuss is about. Maybe I’m not dosing correctly, or maybe my expectations are too steep.”
The passing of the 2018 Farm Bill should usher in a wave of new studies into CBD and diabetes that will provide more conclusive insights. Photo by: Gina Coleman/Weedmaps