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can you overdose on cbd isolate

However, people participating in CBD-related studies have at times reported several side effects, including extreme sleepiness, decreased appetite, diarrhea, fatigue, convulsions, vomiting, and some abnormal results on liver function tests.

On a similar note, the Harvard Health Blog published a post in 2018 regarding adverse effects caused by impurities or contaminants in the CBD, which could exist given the largely unregulated status of cannabis products. Following the passage of the 2018 Farm Bill, hemp-derived CBD products were legalized and placed under the jurisdiction of the United States Food and Drug Administration (FDA).

Can CBD make you sick?

CBD may help improve appetite and promote heart health in dogs, and many CBD-infused dog treats and CBD oil for dogs are readily available on the market. Photo by: Gina Coleman/Weedmaps

If you consume pure CBD, you are unlikely to get sick or experience unpleasant side effects. A 2017 World Health Organization (W.H.O.) report concluded that CBD is “generally well-tolerated with a good safety profile,” and further stated that “in humans, CBD exhibits no effects indicative of any abuse or dependence potential.”

Of course, other factors could complicate the effects of CBD and could be responsible for adverse reactions. For example, adverse effects could stem from an interaction between CBD and the patient’s existing medications.

Schubart CD, Sommer IE, van Gastel WA, et al. Cannabis with high cannabidiol content is associated with fewer psychotic experiences. Schizophr Res 2011;130(1-3):216-21. View abstract.

Serpell MG, Notcutt W, Collin C. Sativex long-term use: an open-label trial in patients with spasticity due to multiple sclerosis. J Neurol 2013;260(1):285-95. View abstract.

Likely Effective for

Collin, C., Davies, P., Mutiboko, I. K., and Ratcliffe, S. Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis. Eur.J.Neurol. 2007;14(3):290-296. View abstract.

Massi P, Solinas M, Cinquina V, Parolaro D. Cannabidiol as a potential anticancer drug. Br J Clin Pharmacol 2013;75(2):303-12. View abstract.

Hess EJ, Moody KA, Geffrey AL, et al. Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex. Epilepsia. 2016 Oct;57(10):1617-24.View abstract.