Ibuprofen specifically targets the COX-1 and COX-2 enzymes by decreasing their activity. These two enzymes trigger inflammation and fever  .
Regardless, CBD remains in conversation as a natural, versatile compound with intriguing effects. But, how effective is it really? This article aims to answer that question.
How Ibuprofen Works
Ibuprofen is derived from propionic acid, the same fatty acid present in processed food. It is primarily used to fight off mould and bacteria, and may severely irritate the skin upon direct interaction. However, the FDA deemed it to have little toxicity  in humans.
On the one hand, you have a fast-acting synthetic drug with known side effects and health risks. On the other, you have an organic substance that’s perceived to have its own benefits—without the risks  . Looking at it on paper, combining the two isn’t such a bad idea.
One review in 2018 (cited from research by Frontiers in Pharmacology) found that CBD might show promise in helping to relieve and manage pain and inflammation.
CBD does not contain THC which causes the high.
NSAIDs certainly have their place, but there are natural options to consider too.
CBD vs Ibuprofen
You might be concerned that CBD and ibuprofen are on that list of do not mix, they’re not, as confirmed by research on drug-drug interactions of CBD (cited from the Journal of Clinal Medicine)
A daily dose of CBD is all natural. You won’t be adding chemicals to your body or having potential side effects from prolonged use of meds.
There are certain substances you shouldn’t mix, such as antibiotics and alcohol.
The way it works is by blocking prostagladins from being produced by non-selectively inhibiting an enzyme called Cyclooxygenase (COX). Prostaglandins are lipid containing substances present all over the body and have hormone like functions. Amongst many types of prostaglandins, some are inflammatory prostaglandins that the body releases when there is an injury or you feel unwell. They’re the cause of pain and inflammation.