Triple Negative Breast Cancer (TNBC) is a difficult type of cancer to treat because it is negative for progesterone, estrogen, and HER-2 receptors. Because TNBC is negative for these three receptors, it does not respond to normal hormonal therapies. The purpose of my experiment is to see if different cannabinoids, compounds from the cannabis plants, could be used as alternative treatment options. These experiments employed three different cannabinoids: ajulemic acid, cannabidiol, and hemp oil. Cell viability was measured after 72 hours of treatment using a MTT assay. The results showed that the three cannabinoids could be used to effectively destroy the TNBC cells. We used this data to calculate the median lethal dose (LD-50), the concentration of the cannabinoid that can be given to destroy half of the cells. Our data suggest, cannabinoids could potentially be used as an alternative treatment for TNBC. However, much more testing would need to be done before it could be confirmed as a viable treatment option.
National Center for Complementary and Integrative Health: “Cannabis (Marijuana) and Cannabinoids: What You Need to Know.”
If you’re taking certain medications like blood thinners and thyroid and seizure medications, you’ll need periodic blood tests to make sure your levels are where they should be. If you’re on a medication like this and you’re going to use CBD products, Mathias Schmucki says, your doctor will need to monitor you to make sure your levels stay on track. “Everybody’s different, so you won’t really know how CBD will affect your body’s metabolism of other medications,” she says.
According to Weiss, some people who use CBD have reported side effects including:
First, let’s break down the terms, which can be confusing.
Keep this in mind, too: “Everyone reacts differently to cannabis products, so don’t feel discouraged if your symptoms aren’t reduced with the first product you try,” Weiss says. “You may need to test different products to find what’s best for you, including the delivery method and dosage.” She suggests starting low and slow, making changes as you go.
“As a doctor, I make the distinction between complementary and alternative medicine,” says Andrea Mathias Schmucki, MD, a patient advocate for the Living Beyond Breast Cancer Hear My Voice advocacy program and a former family physician. She is herself being treated for metastatic breast cancer, or cancer that’s spread to other parts of her body. “I look at CBD as complementary, using it in addition to, rather than as an alternative to, traditional treatment.”
Andrea Mathias Schmucki, MD, patient advocate, Living Beyond Breast Cancer Hear My Voice advocacy program.