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CBD—the abbreviation for cannabidiol, a substance that’s generally derived from the hemp plant—has skyrocketed in popularity over the last five years. In fact, according to some research, “CBD” as a Google search term remained stable from 2004 to 2014 but has since ballooned by up to 605%.

Ultimately, the primary reasons why people use CBD is because it tends to have calming, relaxing, pain-reducing effects. It has been used to alleviate joint pain and nerve pain, reduce anxiety and stress, treat insomnia, improve migraines, and address nausea.

Can Interact With Other Medications

Also known as “cotton mouth,” CBD can potentially cause your mouth and eyes to feel very dry, notes Dr. Brent A. Bauer via Mayo Clinic. Though this side effect is more likely to occur with THC, it can happen with CBD, as well.

She adds, “[Another difference is that] CBD is derived from hemp and has been classified as a legal substance. Hemp has <0.3% THC. Conversely, cannabis plants such as marijuana are grown to have much higher levels of THC and are still illegal according to the FDA, although individual states vary as to their use.”

Wendy Rose Gould is a lifestyle reporter with over a decade of experience covering health and wellness topics.

Learn more here about CBD and cancer.

People should check the laws in their state and any travel destination.

Experts believe that using marijuana during pregnancy may affect the fetal development of neurons. Regular use among teens is associated with issues concerning memory, behavior, and intelligence.

Other neurological symptoms and disorders

CB1 receptors are present throughout the body, particularly in the brain. They co-ordinate movement, pain, emotion, mood, thinking, appetite, memories, and other functions.

In June 2018, the Food and Drug Administration (FDA) approved the prescription use of Epidiolex, a purified form of CBD oil, for treating two types of epilepsy. Other forms of cannabis are legal in other states.

CBD may benefit a person’s health in various ways.

The legal status of CBD in the U.S. is complex. Hemp and hemp-derived products are legal under the Farm Bill, as long as their THC content is less than 0.3%.

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topical cbd and liver

How does it impact the liver?

What is CBD oil?

To further complicate the question, products with CBD oil may not give the exact amount listed on the package . Depending on the brand, the consumer may be using much more or less than they think. This is especially true of OTC supplements and e-cigarettes.

In one study , 10% of the subjects developed high liver enzymes—they had to stop using CBD for this reason. Other research suggests that CBD can improve liver function.

June 4, 2019 by Natalie Shae

The few studies performed on how CBD affects the liver are not clear.

Liver Damage and CBD Oil

Since topical CBD can get absorbed into the bloodstream, it might interact with certain medications.

Due to CBD modulating several cytochrome P450 enzymes, CBD can have an elevated potential of drug interactions.

Recent clinical trials observed elevated liver enzymes in 5-20% of those receiving a chronic administration of CBD in the study, leading to sudden liver failure.

CBD Topical Urine Test

Published in the journal Molecules, consuming extremely high doses of the CBD isolate brand Epidolex can lead to liver toxicity in non-human models.

According to a brief review in the Journal of Pharmacy and Pharmacology, CBD is more polar and has a 10 fold higher permeability than other cannabinoids.

Due to the skin’s low ability to absorb, when applying CBD topicals, it’s recommended you liberally apply enough to overcome the skin’s low absorption rate.

New methods of administering CBD via the skin are in research and development such as using microneedles, patented solutions, and different gel concentrations.

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But it would also make sense why CBD gum would attract golfers, especially older ones like Mickelson and Woods. Not only would CBD calm any nerves in competitive play, it’d also ease any aches and pains a golfer might endure throughout a given tournament.

But Woods proved all the doubters wrong by coming from behind in his victory at Augusta, a feat he’d never previously accomplished. So what was his secret? Long-time fans and golf watchers surely noticed at least one significant change in behavior from Tiger — he was chewing gum. Like, a lot of gum. Whenever the camera cut to Tiger, it seemed his molars were always moving.

The New York Times reported last month that Phil Mickelson recently started chewing gum while golfing “to boost his cognitive function.” Data and research backs up Mickelson’s gummy beliefs. “Studies have shown that chewing gum is associated with improved alertness and the ability to process new information, though the results are far from definitive,” the Times’ Karen Crouse wrote.

“The chewing aspect stimulates the frontal cortex,” added Mickelson.

While we can’t confirm it’s CBD gum they’re chewing, all the signs point to why golfers might consider it. Next time you’re on the links, maybe give it a try. It could just be the difference between a bogey and par in your game.

But some have speculated that Woods and Mickelson aren’t chewing regular old bubblegum — they’re chomping on CBD gum. The PGA Tour’s Anti-Doping Agency usually follows the protocol set by the World Anti-Doping Agency. And when WADA announced athletes could use cannabidiol (CBD), as it didn’t consider the substance performance-enhancing, the PGA Tour adopted similar rules.

Tiger Woods completed one of the greatest comeback stories in sports this past weekend by winning the Masters It’s his first major tournament victory following an 11-year drought that included national scandals, a debilitating back injury, and more. At various points, commentators said any remaining hope around a Tiger comeback was delusional. He’d never win another major tournament, they said.

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A jacketed vessel with stirring will be used to dissolve and crystallize the CBD. A heating/cooling bath is connected to the vessel jacket and will be used to control the temperature of the vessel.

CBD distillate with 70 – 75% CBD content can be crystallized to produce CBD isolate (crystals) with a 90+% purity or higher.

Dissolving CBD Oil

CDB crystals can be re-dissolved and then recrystallized to improve the potency even further.

The mother liquor still contains dissolved CBD. This solution can be reprocessed! One caveat is that the mother liquor will accumulate THC over time. This sets a practical limitation to the number of crystallization.

ACS grade pentane will be the solvent. This can be dangerous stuff. Consult your safety officer!

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The fatty tissue can only hold so much oil, so, theoretically, if you apply enough of a cannabis cream to your skin, it might leak down into your skeletal muscle just out of diffusion, adds Sexton. But there's no study to show this, and that means you're going to be rubbing on a whole lot of the stuff.

Finally, you have receptors called TrpV1 that detect and regulate your body temperature. When activated, they put out heat, soothing your pain receptors. Using this channel, CBD makes these pain receptors hyperactive for a period of time, causing them to get hot, desensitizing them and downregulating those pain-sensing nerve endings.

Interest piqued? Learn more about hemp cream for pain relief and all its variations.

What Science Says About Hemp Creams for Pain Relief

Even still, cannabis creams could still reduce your acute pain or muscle soreness. That's because pretty much all of these hemp pain relief creams on the market right now have other scientifically-proven analgesic compounds, such as menthol, camphor, and capsaicin which are also found in other, non-CBD topical pain relievers. "Any cream with a heating or cooling sensation desensitizes the nerves to pain by distracting them with stimuli on top," explains Dr. Colberg. Plus you're often massaging the area as you apply, which improves circulation and reduces muscle spasms, he adds. (Get the best of both worlds by trying a CBD massage.)

These topical ointments, creams, and lotions are infused with CBD, or cannabidiol, a compound found in the cannabis plant. Manufacturers claim it can help alleviate acute pain and muscle soreness. To reiterate for the uninitiated: CBD is not the same as THC because CBD does not have any psychoactive effects — aka it won't get you high.

"The pain and stiffness that comes post-workout or from overexertion certainly has a pro-inflammatory component to it, so it's reasonable to think CBD or other cannabinoids might have benefits, but we have no research to support this yet," adds Gerdeman.

Science has shown that cannabis is an effective pain reliever, reinforced in a massive new report from the National Academies of Sciences, Engineering, and Medicine. But there's a big difference between ingesting cannabis or its individual chemicals orally and absorbing it topically through your skin.

As it turns out, topical CBD products may offer some anti-inflammatory properties to help alleviate pain through cannabinoid receptors within the skin. These receptors are a part of the body's endocannabinoid system, or ECS, that governs functions such as our ability to process pain, as well as inflammation, mood, and sleep. The cannabis plant contains phytocannabinoids like CBD that interact with our ECS, which is why hemp has therapeutic properties. 

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To buy: 300mg CBDistillery Cooling Cream;

Balm available in 2 oz. jar

This pain relief cream expertly combines broad spectrum CBD extract and other beneficial ingredients to promote joint support and reduce inflammation. Each bottle is made from Colorado-grown hemp plant extract, and this cream is also completely THC-free. All CBDistillery products are fully lab tested and made in America, so you can trust that its products are of the highest quality. CBD cream reviews usually include CBDistillery because of the value the brand offers. The brand also makes one of the best CBD oils.

● Fast-Absorbing Formula: Leaf Remedys Full Spectrum Gel features a formula that works quickly by absorbing into the skin soon after the Gel is applied. This helps with managing pain and inflammation in the affected area faster.

Coming in with four of the best CBD topicals on the market, Medterra easily wins at providing the best variety. Hosting a Pain Relief (with menthol + arnica), Relief + Recovery, Manuka Honey, and Relief + Recovery Roll-On, Medterra additionally enables you to choose from a multitude of strengths per product. Plus, with their Roll-On starting at $19.99, Medterra is driving a great bang for your buck.


Just Live has quickly developed a name for themselves in the CBD industry, likely because of the credibility their founding athletes bring. If there’s one thing we can say about their topicals for pain is that THEY WORK. They really have a product for everyone, whether you’re new to CBD and trying to find a brand to trust or familiar with the space and looking for high dosed topicals for pain, Just Live has a product for you. Their mission is simple, mission is simple, provide high-quality natural wellness products created by athletes – just for you – so you can unlock the life you want to live. Over the counter and prescription pills don’t need to determine how you feel anymore.

● Colorado Grown: The hemp used in the manufacturing of Leaf Remedys products is all locally grown in the Colorado. This Guarantees high quality CBD and gives the manufacturer more control over the growing methods used.

Verma provides an absolute knockout with their performance. An easy-to-use, smart solution, Verma’s topicals help set the standard for relief. As the top contender on our list, they’re a great brand to make your go-to (especially with 25% off for subscription pricing). Year after year Verma Farms has proven to be a winner, with 2021 as no exception.